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• W1753428747 abstract "Research Article15 December 1994free access The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. R. Urfer R. Urfer Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author P. Tsoulfas P. Tsoulfas Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author D. Soppet D. Soppet Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author E. Escandón E. Escandón Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author L.F. Parada L.F. Parada Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author L.G. Presta L.G. Presta Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author R. Urfer R. Urfer Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author P. Tsoulfas P. Tsoulfas Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author D. Soppet D. Soppet Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author E. Escandón E. Escandón Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author L.F. Parada L.F. Parada Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author L.G. Presta L.G. Presta Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. Search for more papers by this author Author Information R. Urfer1, P. Tsoulfas1, D. Soppet1, E. Escandón1, L.F. Parada1 and L.G. Presta1 1Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080. The EMBO Journal (1994)13:5896-5909https://doi.org/10.1002/j.1460-2075.1994.tb06935.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Survival and maintenance of vertebrate neurons are influenced by neurotrophic factors which mediate their signal by binding to specific cell surface receptors. We determined the binding sites of human neurotrophin-3 (NT-3) to its receptors trkC and gp75 by mutational analysis and compared them to the analogous interactions of nerve growth factor (NGF) with trkA and gp75. The trkC binding site extends around the central beta-strand bundle and in contrast to NGF does not make use of non-conserved loops and the six N-terminal residues. The gp75 epitope is dominated by loop residues and the C-terminus of NT-3. A novel rapid biological screening procedure allowed the identification of NT-3 mutants that are able to signal efficiently through the non-preferred receptors trkA and trkB, which are specific for NGF and BDNF respectively. Mutation of only seven residues in NT-3 resulted in a human neurotrophin variant which bound to all receptors of the trk family with high affinity and efficiently supported the survival of NGF-, BDNF- and NT-3-dependent neurons. Our results suggest that the specificity among neurotrophic factors is not solely encoded in sequence diversity, but rather in the way each neurotrophin interacts with its preferred receptor. Previous ArticleNext Article Volume 13Issue 241 December 1994In this issue RelatedDetailsLoading ..." @default.
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• W1753428747 title "The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin." @default.
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• W1753428747 cites W1994986028 @default.
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• W1753428747 cites W2020244870 @default.
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• W1753428747 cites W2068118161 @default.
• W1753428747 cites W2069803121 @default.
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• W1753428747 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06935.x" @default.
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