FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W175392336> ?p ?o ?g. }

• W175392336 endingPage "8" @default.
• W175392336 startingPage "3732" @default.
• W175392336 abstract "To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells.Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphates. Single-cell dynamic fluorescence ratio imaging was used to determine [Ca2+]i.Carbachol, oxotremorine-M, aceclidine, and pilocarpine stimulated PLC with mean EC50s of 20, 8, 17, and 2 microM, respectively. The effect of carbachol on PLC was partially suppressed by extracellular Ca2+ depletion. This muscarinic effect was blocked by muscarinic antagonists, such as atropine (apparent pKi = 9.12, nonselective for muscarinic receptor subtypes), pirenzepine (pKi = 6.76, selective for the M1 receptor subtype), 4DAMP (pKi = 9.25, selective for the M1 and M3 subtypes), and fHHSiD (pKi = 7.77, selective for the M3 subtype). In [Ca2+]i experiments, carbachol increased [Ca2+]i transients in human ciliary muscle cells in a dose-dependent manner with a mean EC50 of 7 microM. 4DAMP was approximately 100 times more potent than pirenzepine in the inhibition of the carbachol-induced [Ca2+]i increase. [Ca2+]i oscillations were observed after carbachol stimulation and persisted after extracellular Ca2+ depletion.Muscarinic agonists activate PLC and increase [Ca2+]i in cultured human ciliary muscle cells through an M3-like muscarinic receptor subtype." @default.
• W175392336 created "2016-06-24" @default.
• W175392336 creator A5023127944 @default.
• W175392336 creator A5027062101 @default.
• W175392336 creator A5042209091 @default.
• W175392336 creator A5073360543 @default.
• W175392336 date "1994-09-01" @default.
• W175392336 modified "2023-09-23" @default.
• W175392336 title "Muscarinic effects on cellular functions in cultured human ciliary muscle cells." @default.
• W175392336 cites W131714981 @default.
• W175392336 cites W1482441851 @default.
• W175392336 cites W1877531625 @default.
• W175392336 cites W1978621039 @default.
• W175392336 cites W1982138262 @default.
• W175392336 cites W2016268802 @default.
• W175392336 cites W2037847885 @default.
• W175392336 cites W2041416738 @default.
• W175392336 cites W2064966546 @default.
• W175392336 cites W2068579383 @default.
• W175392336 cites W2085508015 @default.
• W175392336 cites W2091655143 @default.
• W175392336 cites W2106160398 @default.
• W175392336 cites W2141260882 @default.
• W175392336 cites W2166145769 @default.
• W175392336 cites W2166908412 @default.
• W175392336 cites W2254386607 @default.
• W175392336 cites W2416104181 @default.
• W175392336 cites W303363201 @default.
• W175392336 cites W373409248 @default.
• W175392336 cites W60393999 @default.
• W175392336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8088960" @default.
• W175392336 hasPublicationYear "1994" @default.
• W175392336 type Work @default.
• W175392336 sameAs 175392336 @default.
• W175392336 citedByCount "11" @default.
• W175392336 countsByYear W1753923362016 @default.
• W175392336 countsByYear W1753923362017 @default.
• W175392336 countsByYear W1753923362018 @default.
• W175392336 countsByYear W1753923362022 @default.
• W175392336 countsByYear W1753923362023 @default.
• W175392336 crossrefType "journal-article" @default.
• W175392336 hasAuthorship W175392336A5023127944 @default.
• W175392336 hasAuthorship W175392336A5027062101 @default.
• W175392336 hasAuthorship W175392336A5042209091 @default.
• W175392336 hasAuthorship W175392336A5073360543 @default.
• W175392336 hasConcept C116289061 @default.
• W175392336 hasConcept C126322002 @default.
• W175392336 hasConcept C134018914 @default.
• W175392336 hasConcept C157660682 @default.
• W175392336 hasConcept C169760540 @default.
• W175392336 hasConcept C170493617 @default.
• W175392336 hasConcept C185592680 @default.
• W175392336 hasConcept C207723603 @default.
• W175392336 hasConcept C24998067 @default.
• W175392336 hasConcept C2776961477 @default.
• W175392336 hasConcept C2777204577 @default.
• W175392336 hasConcept C2778186239 @default.
• W175392336 hasConcept C2778597717 @default.
• W175392336 hasConcept C2778616617 @default.
• W175392336 hasConcept C2778824757 @default.
• W175392336 hasConcept C2778988552 @default.
• W175392336 hasConcept C2780718027 @default.
• W175392336 hasConcept C28406088 @default.
• W175392336 hasConcept C33789571 @default.
• W175392336 hasConcept C71924100 @default.
• W175392336 hasConcept C86803240 @default.
• W175392336 hasConcept C95444343 @default.
• W175392336 hasConceptScore W175392336C116289061 @default.
• W175392336 hasConceptScore W175392336C126322002 @default.
• W175392336 hasConceptScore W175392336C134018914 @default.
• W175392336 hasConceptScore W175392336C157660682 @default.
• W175392336 hasConceptScore W175392336C169760540 @default.
• W175392336 hasConceptScore W175392336C170493617 @default.
• W175392336 hasConceptScore W175392336C185592680 @default.
• W175392336 hasConceptScore W175392336C207723603 @default.
• W175392336 hasConceptScore W175392336C24998067 @default.
• W175392336 hasConceptScore W175392336C2776961477 @default.
• W175392336 hasConceptScore W175392336C2777204577 @default.
• W175392336 hasConceptScore W175392336C2778186239 @default.
• W175392336 hasConceptScore W175392336C2778597717 @default.
• W175392336 hasConceptScore W175392336C2778616617 @default.
• W175392336 hasConceptScore W175392336C2778824757 @default.
• W175392336 hasConceptScore W175392336C2778988552 @default.
• W175392336 hasConceptScore W175392336C2780718027 @default.
• W175392336 hasConceptScore W175392336C28406088 @default.
• W175392336 hasConceptScore W175392336C33789571 @default.
• W175392336 hasConceptScore W175392336C71924100 @default.
• W175392336 hasConceptScore W175392336C86803240 @default.
• W175392336 hasConceptScore W175392336C95444343 @default.
• W175392336 hasIssue "10" @default.
• W175392336 hasLocation W1753923361 @default.
• W175392336 hasOpenAccess W175392336 @default.
• W175392336 hasPrimaryLocation W1753923361 @default.
• W175392336 hasRelatedWork W175392336 @default.
• W175392336 hasRelatedWork W1970876703 @default.
• W175392336 hasRelatedWork W1987053385 @default.
• W175392336 hasRelatedWork W1988216302 @default.
• W175392336 hasRelatedWork W1991917044 @default.

• next