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- W1753944887 abstract "Objective To investigate the antibacterial in vivo test of piperacillin sodium and sulbactam sodium for injection(8∶1、4∶1)and piperacillin sodium and tazobactam sodium for injection(8∶1),and compared their ED50 separately.MethodsPPCL-SBT(8∶1)、PPCL-SBT(4∶1)and PPCL-TZBT(8∶1)were given intravenously respectively to the mice,which systemically infected by S.aureus,K.pneumoniae and E.coli,then the ED50 were calculated.ResultsThe ED50 of PPCL-SBT(8∶1),PPCL-SBT(4∶1)and PPCL-TZBT(8∶1)against S.aureus were 803.8,947.8 and 785.7 mg/kg respectively;the ED50 of them against K.pneumoniae were 685.4,670.1 and 544.5 mg/kg respectively;the ED50 of PPCL-SBT(8∶1)、PPCL-SBT(4∶1)and PPCL-TZBT(8∶1)against E.coli were 1 108.7,1 133.9 and 1 076.4 mg/kg respectively.There was no significant difference in their ED50(P0.05).ConclusionPPCL-SBT(8∶1)、PPCL-SBT(4∶1)and PPCL-TZBT(8∶1)have relatively good protection to the mice provoked by S.aureus,K.pneumoniae and E.coli,and the antibacterial activity in vivo of them are the same." @default.
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- W1753944887 date "2009-01-01" @default.
- W1753944887 modified "2023-09-26" @default.
- W1753944887 title "Comparative study on pharmacodynamics of piperacillin sodium and sulbactam sodium for injection (8:1)." @default.
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