Matches in SemOpenAlex for { <https://semopenalex.org/work/W1753999167> ?p ?o ?g. }
- W1753999167 endingPage "73" @default.
- W1753999167 startingPage "66" @default.
- W1753999167 abstract "Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes. In addition to its effects improving insulin sensitivity, FGF21 causes weight loss by increasing energy expenditure. Activation of the thermogenic activity of brown adipose tissue and promotion of the appearance of the so-called beige/brite type of brown adipocytes in white fat are considered the main mechanisms underlying the leaning effects of FGF21. Paradoxically, however, obesity in rodents and humans is characterized by high levels of FGF21 in the blood. Some degree of resistance to the actions of FGF21 has been proposed as part of the endocrine alterations in obesity. The resistance in adipose tissue from obese rodents and patients is likely attributable to abnormally low levels of the FGF co-receptor β-Klotho, required for FGF21 cellular action. However, native FGF21 and FGF21 derivatives retain their healthy metabolic and weight-loss effects when used as pharmacological agents to treat obese rodents and humans. FGF21 derivatives or molecules mimicking FGF21 action appear to be interesting candidates for the development of novel anti-obesity drugs designed to increase energy expenditure." @default.
- W1753999167 created "2016-06-24" @default.
- W1753999167 creator A5003437583 @default.
- W1753999167 creator A5054088943 @default.
- W1753999167 creator A5067007507 @default.
- W1753999167 date "2015-12-01" @default.
- W1753999167 modified "2023-10-17" @default.
- W1753999167 title "Fibroblast growth factor-21, energy balance and obesity" @default.
- W1753999167 cites W1522113235 @default.
- W1753999167 cites W1697181819 @default.
- W1753999167 cites W1963690531 @default.
- W1753999167 cites W1965079305 @default.
- W1753999167 cites W1966181749 @default.
- W1753999167 cites W1968091833 @default.
- W1753999167 cites W1970362460 @default.
- W1753999167 cites W1973870014 @default.
- W1753999167 cites W1973873267 @default.
- W1753999167 cites W1975685675 @default.
- W1753999167 cites W1977994465 @default.
- W1753999167 cites W1978039711 @default.
- W1753999167 cites W1980767631 @default.
- W1753999167 cites W1983477298 @default.
- W1753999167 cites W1986602268 @default.
- W1753999167 cites W1988869711 @default.
- W1753999167 cites W1989584881 @default.
- W1753999167 cites W1998338586 @default.
- W1753999167 cites W2000665430 @default.
- W1753999167 cites W2002182028 @default.
- W1753999167 cites W2005063766 @default.
- W1753999167 cites W2005827500 @default.
- W1753999167 cites W2006024610 @default.
- W1753999167 cites W2006193186 @default.
- W1753999167 cites W2009439595 @default.
- W1753999167 cites W2011349880 @default.
- W1753999167 cites W2012853495 @default.
- W1753999167 cites W2013900763 @default.
- W1753999167 cites W2015132915 @default.
- W1753999167 cites W2017422378 @default.
- W1753999167 cites W2017843740 @default.
- W1753999167 cites W2020263289 @default.
- W1753999167 cites W2021760176 @default.
- W1753999167 cites W2025870139 @default.
- W1753999167 cites W2027753197 @default.
- W1753999167 cites W2028284381 @default.
- W1753999167 cites W2030086415 @default.
- W1753999167 cites W2030136738 @default.
- W1753999167 cites W2037001212 @default.
- W1753999167 cites W2037871722 @default.
- W1753999167 cites W2040328785 @default.
- W1753999167 cites W2041451676 @default.
- W1753999167 cites W2042911346 @default.
- W1753999167 cites W2046067052 @default.
- W1753999167 cites W2047726905 @default.
- W1753999167 cites W2048411348 @default.
- W1753999167 cites W2050259739 @default.
- W1753999167 cites W2050494576 @default.
- W1753999167 cites W2054119106 @default.
- W1753999167 cites W2056045775 @default.
- W1753999167 cites W2062073832 @default.
- W1753999167 cites W2062842771 @default.
- W1753999167 cites W2064125892 @default.
- W1753999167 cites W2067576104 @default.
- W1753999167 cites W2067641381 @default.
- W1753999167 cites W2070126973 @default.
- W1753999167 cites W2073654379 @default.
- W1753999167 cites W2074720398 @default.
- W1753999167 cites W2076210772 @default.
- W1753999167 cites W2077799214 @default.
- W1753999167 cites W2082930819 @default.
- W1753999167 cites W2098457930 @default.
- W1753999167 cites W2098667700 @default.
- W1753999167 cites W2106986971 @default.
- W1753999167 cites W2108364290 @default.
- W1753999167 cites W2109071746 @default.
- W1753999167 cites W2111517662 @default.
- W1753999167 cites W2111653877 @default.
- W1753999167 cites W2112076976 @default.
- W1753999167 cites W2114650931 @default.
- W1753999167 cites W2114821999 @default.
- W1753999167 cites W2115774842 @default.
- W1753999167 cites W2119331212 @default.
- W1753999167 cites W2119351413 @default.
- W1753999167 cites W2121049950 @default.
- W1753999167 cites W2127359651 @default.
- W1753999167 cites W2129631252 @default.
- W1753999167 cites W2131044927 @default.
- W1753999167 cites W2131192628 @default.
- W1753999167 cites W2131622156 @default.
- W1753999167 cites W2132358997 @default.
- W1753999167 cites W2133573974 @default.
- W1753999167 cites W2134810803 @default.
- W1753999167 cites W2134898018 @default.
- W1753999167 cites W2134944069 @default.
- W1753999167 cites W2136624264 @default.
- W1753999167 cites W2136769963 @default.
- W1753999167 cites W2137438007 @default.
- W1753999167 cites W2138707492 @default.
- W1753999167 cites W2144461742 @default.