FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1754013592> ?p ?o ?g. }

• W1754013592 endingPage "551" @default.
• W1754013592 startingPage "543" @default.
• W1754013592 abstract "Type 1 diabetes is a complex disease where numerous genes are involved in the pathogenesis. Genes that account for approximately 50% of the familial clustering of the disease are located within or in the vicinity of the HLA complex on chromosome 6. Some DRB1, DQA1 and DQB1 genes are known to be involved, in addition to as yet unidentified HLA-linked genes. The DR4-DQ8 and DR3-DQ2 haplotypes are known to confer high risk for developing the disease, particularly when occurring together. Approximately 10% of patients, however, do not carry any of these high-risk HLA class II haplotypes. We have performed genotyping of DRB1, DQA1 and DQB1 alleles in non-DR3-DQ2/non-DR4-DQ8 patients and controls from Sweden and Norway to test if any HLA associations were observed in these patients. Our results clearly demonstrate several statistically significant differences in the frequency of HLA haplotypes between patients and controls. Case-control analysis including the relative predispositional effect test, and transmission disequilibrium test (TDT) analysis in Norwegian type 1 diabetes families revealed that the DQA1*03-DQB1*0301, DQA1*0401-DQB1*0402, DQA1*0101-DQB1*0501, DQA1*03-DQB1*0303 and DQA1*0102-DQB1*0604 haplotypes may also confer risk. Our analyses also supported independent risks of certain DRB1 alleles. The study clearly demonstrates that HLA associations in type 1 diabetes extends far beyond the well-known associations with the DR4-DQ8 and DR3-DQ2 haplotypes. Our data suggest that there is a hierarchy of HLA class II haplotypes conferring risk to develop type 1 diabetes." @default.
• W1754013592 created "2016-06-24" @default.
• W1754013592 creator A5008841181 @default.
• W1754013592 creator A5008943002 @default.
• W1754013592 creator A5036154593 @default.
• W1754013592 creator A5049463864 @default.
• W1754013592 creator A5055043798 @default.
• W1754013592 creator A5057254866 @default.
• W1754013592 creator A5070358488 @default.
• W1754013592 creator A5070458733 @default.
• W1754013592 creator A5081702829 @default.
• W1754013592 creator A5089120555 @default.
• W1754013592 date "1999-12-01" @default.
• W1754013592 modified "2023-10-02" @default.
• W1754013592 title "HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes" @default.
• W1754013592 cites W1981009470 @default.
• W1754013592 cites W1983974380 @default.
• W1754013592 cites W1990040680 @default.
• W1754013592 cites W1990704381 @default.
• W1754013592 cites W1991086155 @default.
• W1754013592 cites W1991727705 @default.
• W1754013592 cites W1993658090 @default.
• W1754013592 cites W1996111489 @default.
• W1754013592 cites W1997868479 @default.
• W1754013592 cites W2002305096 @default.
• W1754013592 cites W2003292000 @default.
• W1754013592 cites W2057352224 @default.
• W1754013592 cites W2070721279 @default.
• W1754013592 cites W2072015807 @default.
• W1754013592 cites W2074891952 @default.
• W1754013592 cites W2077464731 @default.
• W1754013592 cites W2078292064 @default.
• W1754013592 cites W2079490247 @default.
• W1754013592 cites W2079542677 @default.
• W1754013592 cites W2086914866 @default.
• W1754013592 cites W2095241809 @default.
• W1754013592 cites W2097575675 @default.
• W1754013592 cites W2099000356 @default.
• W1754013592 cites W2105423805 @default.
• W1754013592 cites W2155903121 @default.
• W1754013592 cites W2156989422 @default.
• W1754013592 cites W2170946887 @default.
• W1754013592 cites W2182205274 @default.
• W1754013592 cites W2288736729 @default.
• W1754013592 doi "https://doi.org/10.1034/j.1399-0039.1999.540602.x" @default.
• W1754013592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10674967" @default.
• W1754013592 hasPublicationYear "1999" @default.
• W1754013592 type Work @default.
• W1754013592 sameAs 1754013592 @default.
• W1754013592 citedByCount "34" @default.
• W1754013592 countsByYear W17540135922012 @default.
• W1754013592 countsByYear W17540135922014 @default.
• W1754013592 countsByYear W17540135922018 @default.
• W1754013592 countsByYear W17540135922019 @default.
• W1754013592 crossrefType "journal-article" @default.
• W1754013592 hasAuthorship W1754013592A5008841181 @default.
• W1754013592 hasAuthorship W1754013592A5008943002 @default.
• W1754013592 hasAuthorship W1754013592A5036154593 @default.
• W1754013592 hasAuthorship W1754013592A5049463864 @default.
• W1754013592 hasAuthorship W1754013592A5055043798 @default.
• W1754013592 hasAuthorship W1754013592A5057254866 @default.
• W1754013592 hasAuthorship W1754013592A5070358488 @default.
• W1754013592 hasAuthorship W1754013592A5070458733 @default.
• W1754013592 hasAuthorship W1754013592A5081702829 @default.
• W1754013592 hasAuthorship W1754013592A5089120555 @default.
• W1754013592 hasConcept C104317684 @default.
• W1754013592 hasConcept C126322002 @default.
• W1754013592 hasConcept C135763542 @default.
• W1754013592 hasConcept C147483822 @default.
• W1754013592 hasConcept C180754005 @default.
• W1754013592 hasConcept C188280979 @default.
• W1754013592 hasConcept C197754878 @default.
• W1754013592 hasConcept C2776885448 @default.
• W1754013592 hasConcept C2779134260 @default.
• W1754013592 hasConcept C31467283 @default.
• W1754013592 hasConcept C35605836 @default.
• W1754013592 hasConcept C54355233 @default.
• W1754013592 hasConcept C71924100 @default.
• W1754013592 hasConcept C86803240 @default.
• W1754013592 hasConceptScore W1754013592C104317684 @default.
• W1754013592 hasConceptScore W1754013592C126322002 @default.
• W1754013592 hasConceptScore W1754013592C135763542 @default.
• W1754013592 hasConceptScore W1754013592C147483822 @default.
• W1754013592 hasConceptScore W1754013592C180754005 @default.
• W1754013592 hasConceptScore W1754013592C188280979 @default.
• W1754013592 hasConceptScore W1754013592C197754878 @default.
• W1754013592 hasConceptScore W1754013592C2776885448 @default.
• W1754013592 hasConceptScore W1754013592C2779134260 @default.
• W1754013592 hasConceptScore W1754013592C31467283 @default.
• W1754013592 hasConceptScore W1754013592C35605836 @default.
• W1754013592 hasConceptScore W1754013592C54355233 @default.
• W1754013592 hasConceptScore W1754013592C71924100 @default.
• W1754013592 hasConceptScore W1754013592C86803240 @default.
• W1754013592 hasIssue "6" @default.
• W1754013592 hasLocation W17540135921 @default.
• W1754013592 hasLocation W17540135922 @default.
• W1754013592 hasOpenAccess W1754013592 @default.
• W1754013592 hasPrimaryLocation W17540135921 @default.

• next