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- W1754241820 endingPage "216" @default.
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- W1754241820 abstract "Abstract Primary brain tumors occur in 8 out of 100 000 people and are the leading cause of cancer‐related death in children. Among brain tumors, high‐grade astrocytomas ( HGAs ) including glioblastoma multiforme ( GBM ) are aggressive and are lethal human cancers. Despite decades of concerted therapeutic efforts, HGAs remain essentially incurable in adults and children. Recent discoveries have revolutionized our understanding of these tumors in children and young adults. Recurrent somatic driver mutations in the tail of histone 3 variant 3 ( H 3.3), leading to amino acid substitutions at key residues, namely lysine ( K ) 27 ( K27M ) and glycine 34 ( G34R/G34V ), were identified as a new molecular mechanism in pediatric GBM . These mutations represent the pediatric counterpart of the recurrent mutations in isocitrate dehydrogenases ( IDH ) identified in young adult gliomas and provide a much‐needed new pathway that can be targeted for therapeutic development. This review will provide an overview of the potential role of these mutations in altering chromatin structure and affecting specific molecular pathways ultimately leading to gliomagenesis. The distinct changes in chromatin structure and the specific downstream events induced by each mutation need characterizing independently if progress is to be made in tackling this devastating cancer." @default.
- W1754241820 created "2016-06-24" @default.
- W1754241820 creator A5015267609 @default.
- W1754241820 creator A5054560949 @default.
- W1754241820 creator A5069822100 @default.
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- W1754241820 date "2013-02-25" @default.
- W1754241820 modified "2023-10-17" @default.
- W1754241820 title "Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail" @default.
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- W1754241820 cites W1966218941 @default.
- W1754241820 cites W1968637358 @default.
- W1754241820 cites W1968931043 @default.
- W1754241820 cites W1970916644 @default.
- W1754241820 cites W1973751980 @default.
- W1754241820 cites W1980754306 @default.
- W1754241820 cites W1985300614 @default.
- W1754241820 cites W1986009297 @default.
- W1754241820 cites W1987822177 @default.
- W1754241820 cites W1988756388 @default.
- W1754241820 cites W1999969244 @default.
- W1754241820 cites W2000229680 @default.
- W1754241820 cites W2014070225 @default.
- W1754241820 cites W2015735594 @default.
- W1754241820 cites W2015755329 @default.
- W1754241820 cites W2024373518 @default.
- W1754241820 cites W2025183726 @default.
- W1754241820 cites W2025238642 @default.
- W1754241820 cites W2028643362 @default.
- W1754241820 cites W2033130827 @default.
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- W1754241820 cites W2040827479 @default.
- W1754241820 cites W2042268063 @default.
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- W1754241820 cites W2052609775 @default.
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- W1754241820 cites W2060605982 @default.
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- W1754241820 cites W2066899457 @default.
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- W1754241820 cites W2074591493 @default.
- W1754241820 cites W2075297104 @default.
- W1754241820 cites W2080452140 @default.
- W1754241820 cites W2080629063 @default.
- W1754241820 cites W2082080058 @default.
- W1754241820 cites W2090954579 @default.
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- W1754241820 doi "https://doi.org/10.1111/bpa.12023" @default.
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