FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W175479904> ?p ?o ?g. }

• W175479904 endingPage "1237" @default.
• W175479904 startingPage "1232" @default.
• W175479904 abstract "A complete molecular description of the syndromes of graft-versus-host disease (GVHD) and graft rejection could have a significant impact on clinical bone marrow transplantation. Recent in vitro experiments (Heusel et al, Cell 76:977, 1994 and Shresta et al, Proc Natl Acad Sci USA 92:5679, 1995) have shown that the putative mediators of these two syndromes, cytotoxic lymphocytes (CTL) and natural killer (NK) cells, respectively, initiate a program of cell death (apoptosis) in susceptible target tissues in a manner critically dependent on the serine protease Granzyme B (gzm B). In the present study, we have analyzed the phenotype of gzm B-deficient mice using experimental transplant models designed to isolate their CD8+ CTL, CD4+ CTL, and NK compartments. We found a significant impairment in class I-dependent GVHD mediated by gzm B -/- CD8+ CTL, whereas class II-dependent GVHD was not altered using gzm B -/- CD4+ effectors. In a hybrid resistance model, gzm B -/- hosts rejected haplo-identical marrow grafts as efficiently as did their wild-type littermates. This result is surprising in light of a severe defect in the ability of gzm B -/- NK cells to induce apoptosis in susceptible targets in vitro. These in vivo data define significant role for gzm B in cytotoxicity mediated by CD8+ CTL, but not by CD4+ CTL. Furthermore, these results do not support a model of hybrid resistance in which NK cells play a pivotal role." @default.
• W175479904 created "2016-06-24" @default.
• W175479904 creator A5056921013 @default.
• W175479904 creator A5076598094 @default.
• W175479904 creator A5090261588 @default.
• W175479904 date "1996-02-15" @default.
• W175479904 modified "2023-10-02" @default.
• W175479904 title "The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection" @default.
• W175479904 cites W1499992835 @default.
• W175479904 cites W1539572779 @default.
• W175479904 cites W1540441814 @default.
• W175479904 cites W1587508560 @default.
• W175479904 cites W1603292182 @default.
• W175479904 cites W1922622614 @default.
• W175479904 cites W193978997 @default.
• W175479904 cites W1964662853 @default.
• W175479904 cites W1969914430 @default.
• W175479904 cites W1973792489 @default.
• W175479904 cites W1974733889 @default.
• W175479904 cites W1979300931 @default.
• W175479904 cites W1979323848 @default.
• W175479904 cites W1981182552 @default.
• W175479904 cites W1991476335 @default.
• W175479904 cites W1993116214 @default.
• W175479904 cites W1997378038 @default.
• W175479904 cites W2005562856 @default.
• W175479904 cites W2005765588 @default.
• W175479904 cites W2025687870 @default.
• W175479904 cites W2027611582 @default.
• W175479904 cites W2034760582 @default.
• W175479904 cites W2050531443 @default.
• W175479904 cites W2056924500 @default.
• W175479904 cites W2064706357 @default.
• W175479904 cites W2073914550 @default.
• W175479904 cites W2078374858 @default.
• W175479904 cites W2083079495 @default.
• W175479904 cites W2129080097 @default.
• W175479904 cites W2131282129 @default.
• W175479904 cites W2133287830 @default.
• W175479904 cites W2134110351 @default.
• W175479904 cites W2161020639 @default.
• W175479904 cites W2396641475 @default.
• W175479904 doi "https://doi.org/10.1182/blood.v87.4.1232.bloodjournal8741232" @default.
• W175479904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8608209" @default.
• W175479904 hasPublicationYear "1996" @default.
• W175479904 type Work @default.
• W175479904 sameAs 175479904 @default.
• W175479904 citedByCount "124" @default.
• W175479904 countsByYear W1754799042012 @default.
• W175479904 countsByYear W1754799042013 @default.
• W175479904 countsByYear W1754799042014 @default.
• W175479904 countsByYear W1754799042015 @default.
• W175479904 countsByYear W1754799042016 @default.
• W175479904 countsByYear W1754799042017 @default.
• W175479904 countsByYear W1754799042018 @default.
• W175479904 countsByYear W1754799042019 @default.
• W175479904 countsByYear W1754799042020 @default.
• W175479904 countsByYear W1754799042021 @default.
• W175479904 countsByYear W1754799042022 @default.
• W175479904 countsByYear W1754799042023 @default.
• W175479904 crossrefType "journal-article" @default.
• W175479904 hasAuthorship W175479904A5056921013 @default.
• W175479904 hasAuthorship W175479904A5076598094 @default.
• W175479904 hasAuthorship W175479904A5090261588 @default.
• W175479904 hasBestOaLocation W1754799041 @default.
• W175479904 hasConcept C147969180 @default.
• W175479904 hasConcept C154317977 @default.
• W175479904 hasConcept C167672396 @default.
• W175479904 hasConcept C183193105 @default.
• W175479904 hasConcept C202751555 @default.
• W175479904 hasConcept C203014093 @default.
• W175479904 hasConcept C2776062744 @default.
• W175479904 hasConcept C2779968557 @default.
• W175479904 hasConcept C2779972918 @default.
• W175479904 hasConcept C2780380082 @default.
• W175479904 hasConcept C28328180 @default.
• W175479904 hasConcept C55493867 @default.
• W175479904 hasConcept C86803240 @default.
• W175479904 hasConcept C8891405 @default.
• W175479904 hasConcept C95444343 @default.
• W175479904 hasConceptScore W175479904C147969180 @default.
• W175479904 hasConceptScore W175479904C154317977 @default.
• W175479904 hasConceptScore W175479904C167672396 @default.
• W175479904 hasConceptScore W175479904C183193105 @default.
• W175479904 hasConceptScore W175479904C202751555 @default.
• W175479904 hasConceptScore W175479904C203014093 @default.
• W175479904 hasConceptScore W175479904C2776062744 @default.
• W175479904 hasConceptScore W175479904C2779968557 @default.
• W175479904 hasConceptScore W175479904C2779972918 @default.
• W175479904 hasConceptScore W175479904C2780380082 @default.
• W175479904 hasConceptScore W175479904C28328180 @default.
• W175479904 hasConceptScore W175479904C55493867 @default.
• W175479904 hasConceptScore W175479904C86803240 @default.
• W175479904 hasConceptScore W175479904C8891405 @default.
• W175479904 hasConceptScore W175479904C95444343 @default.
• W175479904 hasIssue "4" @default.
• W175479904 hasLocation W1754799041 @default.
• W175479904 hasOpenAccess W175479904 @default.

• next