FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1754858407> ?p ?o ?g. }

• W1754858407 endingPage "482" @default.
• W1754858407 startingPage "477" @default.
• W1754858407 abstract "The expression of protein kinase C (PKC) isoenzymes and the effects of PKC activation on myocardial phospholipase A2 (PLA2) activity, platelet-activating factor (PAF) generation and eicosanoid release were studied in spontaneously beating cultured rat cardiomyocytes. Western blotting analysis indicated that these cells contain PKC alpha, beta, delta and zeta, but not PKC gamma or epsilon. Stimulation of cardiomyocytes with 4 beta-phorbol 12-myristate 13-acetate (PMA) led to a rapid increase in particulate-bound PKC activity, a response attributed to the activation of alpha-, delta- and zeta- type PKCs but not beta-type PKC. Translocation of PKC alpha, delta and zeta was accompanied by simultaneous increases in cellular lysophosphatidylcholine (lyso-PC), PAF, 15(S)-hydroxy-5,8,-11,13-eicosatetraenoic acid (15-HETE), prostaglandin E2 (PGE2) and prostacyclin (PGI2) generation, suggesting that one or more of these isoenzymes directly or indirectly activates a PLA2 in these cells. Confirming this, 4 beta-phorbol 12-monoacetate and 4 alpha-phorbol had no effect on cellular eicosanoid formation, while the PMA-induced response was fully abolished both in the presence of the PKC inhibitors staurosporine and CGP 41251 and in PKC-down-regulated cells. PKC alpha, delta and/or zeta therefore appear to play an important role in the PMA-mediated activation of cardiomyocyte PLA2, an event leading to subsequent production of PGI2, PGE2, 15-HETE, lyso-PC and PAF in this tissue." @default.
• W1754858407 created "2016-06-24" @default.
• W1754858407 creator A5001336156 @default.
• W1754858407 creator A5053375948 @default.
• W1754858407 creator A5061024845 @default.
• W1754858407 creator A5073307660 @default.
• W1754858407 date "1993-03-01" @default.
• W1754858407 modified "2023-09-27" @default.
• W1754858407 title "Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes" @default.
• W1754858407 cites W1428583350 @default.
• W1754858407 cites W1491529911 @default.
• W1754858407 cites W1495423595 @default.
• W1754858407 cites W1498021746 @default.
• W1754858407 cites W1500109801 @default.
• W1754858407 cites W1500482096 @default.
• W1754858407 cites W1507801782 @default.
• W1754858407 cites W1508152421 @default.
• W1754858407 cites W1543557663 @default.
• W1754858407 cites W1557423604 @default.
• W1754858407 cites W1567170846 @default.
• W1754858407 cites W1581760931 @default.
• W1754858407 cites W1586296071 @default.
• W1754858407 cites W1592772777 @default.
• W1754858407 cites W1603439931 @default.
• W1754858407 cites W1668450698 @default.
• W1754858407 cites W1993282564 @default.
• W1754858407 cites W1997225360 @default.
• W1754858407 cites W2007083974 @default.
• W1754858407 cites W2009087603 @default.
• W1754858407 cites W2016717357 @default.
• W1754858407 cites W2018289835 @default.
• W1754858407 cites W2028749092 @default.
• W1754858407 cites W2041556575 @default.
• W1754858407 cites W2048401395 @default.
• W1754858407 cites W2051531396 @default.
• W1754858407 cites W2052811636 @default.
• W1754858407 cites W2055702210 @default.
• W1754858407 cites W2057046458 @default.
• W1754858407 cites W2072167868 @default.
• W1754858407 cites W2080933052 @default.
• W1754858407 cites W2083982621 @default.
• W1754858407 cites W2093927588 @default.
• W1754858407 cites W2101108802 @default.
• W1754858407 cites W2142339245 @default.
• W1754858407 cites W2186202324 @default.
• W1754858407 cites W2321591535 @default.
• W1754858407 cites W2416526095 @default.
• W1754858407 cites W532807 @default.
• W1754858407 doi "https://doi.org/10.1042/bj2900477" @default.
• W1754858407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1132298" @default.
• W1754858407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8452537" @default.
• W1754858407 hasPublicationYear "1993" @default.
• W1754858407 type Work @default.
• W1754858407 sameAs 1754858407 @default.
• W1754858407 citedByCount "56" @default.
• W1754858407 countsByYear W17548584072012 @default.
• W1754858407 countsByYear W17548584072017 @default.
• W1754858407 countsByYear W17548584072018 @default.
• W1754858407 countsByYear W17548584072020 @default.
• W1754858407 countsByYear W17548584072023 @default.
• W1754858407 crossrefType "journal-article" @default.
• W1754858407 hasAuthorship W1754858407A5001336156 @default.
• W1754858407 hasAuthorship W1754858407A5053375948 @default.
• W1754858407 hasAuthorship W1754858407A5061024845 @default.
• W1754858407 hasAuthorship W1754858407A5073307660 @default.
• W1754858407 hasBestOaLocation W17548584072 @default.
• W1754858407 hasConcept C115302286 @default.
• W1754858407 hasConcept C126322002 @default.
• W1754858407 hasConcept C134018914 @default.
• W1754858407 hasConcept C153911025 @default.
• W1754858407 hasConcept C181199279 @default.
• W1754858407 hasConcept C185592680 @default.
• W1754858407 hasConcept C195794163 @default.
• W1754858407 hasConcept C2776330855 @default.
• W1754858407 hasConcept C2776352991 @default.
• W1754858407 hasConcept C2776551241 @default.
• W1754858407 hasConcept C2778078955 @default.
• W1754858407 hasConcept C2778596009 @default.
• W1754858407 hasConcept C2778918659 @default.
• W1754858407 hasConcept C2779084600 @default.
• W1754858407 hasConcept C2780043322 @default.
• W1754858407 hasConcept C2781128415 @default.
• W1754858407 hasConcept C41625074 @default.
• W1754858407 hasConcept C55493867 @default.
• W1754858407 hasConcept C62478195 @default.
• W1754858407 hasConcept C71924100 @default.
• W1754858407 hasConcept C86803240 @default.
• W1754858407 hasConcept C95444343 @default.
• W1754858407 hasConceptScore W1754858407C115302286 @default.
• W1754858407 hasConceptScore W1754858407C126322002 @default.
• W1754858407 hasConceptScore W1754858407C134018914 @default.
• W1754858407 hasConceptScore W1754858407C153911025 @default.
• W1754858407 hasConceptScore W1754858407C181199279 @default.
• W1754858407 hasConceptScore W1754858407C185592680 @default.
• W1754858407 hasConceptScore W1754858407C195794163 @default.
• W1754858407 hasConceptScore W1754858407C2776330855 @default.
• W1754858407 hasConceptScore W1754858407C2776352991 @default.
• W1754858407 hasConceptScore W1754858407C2776551241 @default.

• next