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- W1754870410 abstract "B cells secrete antibodies that mediate protection against a great variety of pathogens. There are two classes of antigens for B cells, T cell-dependent (thymus-dependent, TD) and T cell-independent (TI) antigens. The former require the presence of cognate T-helper (TH) cells to trigger a B-cell response, whereas the TI antigens can mount an antibody response in the absence of TH. A large class of antigens, namely proteins on pathogen surfaces, are both TI and TD: They are able to induce a TI IgM (immunoglobulin M) antibody response, since they are highly repetitive and linked to toll-like receptor (TLR) ligands and they induce a TD response, since they are proteins. Epitope repetitiveness, presence of TLR-ligands and T help together shape the quantity, quality and duration of an antibody response.Key Concepts: TI antigens induce antibody responses in the absence of TH.TI antibody responses are mostly of the IgM isotype and short-lived.TD antigens require TH cells to induce an antibody responses.TD antibody responses are usually of the IgG isotype and more long-lived.Pathogens are complex antigens and are both TI (they are repetitive and contain TLR ligands) and TD (they contain proteins and induce TH).This combination of TI and TD makes pathogens such strong immunogens for B cells.Antigen-repetitiveness and presence of TLR ligands modulate the overall magnitude of the antibody responses.Presence of TH imprints memory into the antibody responses by allowing the formation of long-lived plasma cells as well as memory B cells.Keywords:antibody;vaccine;T/B collaboration;toll-like receptor ligands" @default.
- W1754870410 created "2016-06-24" @default.
- W1754870410 creator A5030120350 @default.
- W1754870410 date "2009-09-15" @default.
- W1754870410 modified "2023-09-25" @default.
- W1754870410 title "Antigens: Thymus-dependent" @default.
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- W1754870410 doi "https://doi.org/10.1002/9780470015902.a0000502.pub2" @default.
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