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- W1755009528 abstract "Lennox-Gastaut syndrome (LGS) is a pediatric epileptic encephalopathy, which is characterized by uncontrolled seizures, diffuse slow spike and wave discharges on encephalogram, and cognitive impairment. This is a severe form of childhood epilepsy, pharmacoresistant in most cases, with a peak incidence between the ages of 3 and 5 years. Mental retardation is common attributed to increased frequency of seizures. Rufinamide approval by Food and Drug Administration gave new hope to patients and their caregivers. Rufinamide is a third generation anticonvulsant, which is structurally different from other anticonvulsants. Clinical trials of rufinamide have shown a decreased frequency of seizures including atonic seizures and drop attacks in patients with LGS. In this current paper, we discuss the role of rufinamide as a new option in the management of this childhood epileptic encephalopathy." @default.
- W1755009528 created "2016-06-24" @default.
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- W1755009528 date "2015-07-18" @default.
- W1755009528 modified "2023-09-26" @default.
- W1755009528 title "Management of Lennox-Gastaut syndrome with rufinamide" @default.
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- W1755009528 doi "https://doi.org/10.3233/pep-13049" @default.
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