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- W1755171570 abstract "COPD (chronic obstructive pulmonary disease) is a chronic progressive inflammatory disease characterised by limitations in lung airflow that is not fully reversible. The concentrations and correlations of TNF-a, CXCL8, big ET-1 and hsCRP were investigated in healthy non-smokers, healthy smokers and patients with COPD in order to study their possible role in the pathophysiology of COPD. The concentrations of TNF-a, CXCL8 and big ET-1 were not statistically different between the experimental groups. No significant differences for the measured analytes were found between smokers and the non-smokers in the control group. The Spearman coefficient of correlation between the concentrations of TNF-a and CXCL8 was r = 0.638 (p<0.0001). However, the concentration of hsCRP was significantly higher in patients with COPD than in the control group (p = 0.0004). hsCRP proved to be a more sensitive diagnostic parameter than TNF-a, CXCL8 and big ET-1 in the systemic circulation in patients with COPD." @default.
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- W1755171570 date "2008-04-15" @default.
- W1755171570 modified "2023-09-26" @default.
- W1755171570 title "TNF-alpha, CXCL8, big ET-1 and hsCRP in patients with chronic obstructive pulmonary disease" @default.
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