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• W1755276168 endingPage "F138" @default.
• W1755276168 startingPage "F129" @default.
• W1755276168 abstract "In diverse cell types, ankyrin tethers a variety of ion transport and cell adhesion molecules to the spectrin-based membrane skeleton. In the whole kidney, epithelial ankyrin (Ank3) is the predominantly expressed ankyrin and is expressed as distinct spliceoforms. Antibodies against a portion of the Ank3 regulatory domain detected four major spliceoforms at 215, 200, 170, and 120 kDa. Immunoblotting of the renal cortex, which is 80% proximal tubule (PT), detected all four spliceoforms but showed significantly diminished Ank3 200/215 . To determine the Ank3 spliceoforms present in the mouse PT cells, PT fragments were purified to 100% from the renal cortex. Isolation was performed by incubating cortical tubule segments with fluorescein and isolating the fluorescein-laden PT fragments or fluorescein-deplete non-PT (distal) fragments under fluorescence microscopy. Distal tubule (DT) fragments displayed abundance of the Ank3 200/215 but no Ank3 170 or Ank3 120 . Isolated PT segments contained all four spliceoforms but dramatically diminished Ank3 200/215 . These larger spliceoforms bind Na-K-ATPase in diverse cell types. Densitometric analysis of Ank3 200/215 and Na-K-ATPase abundance measured a lower Ank3 200/215 -to-Na-K-ATPase ratio in the PT vs. the renal cortex. These proximal vs. distal differences in Ank3 spliceoforms were displayed in LLC-PK 1 cells, a proximal cell line, and MDCK cells, a distal cell line. The lower PT content of Ank3 200/215 suggests Na-K-ATPase in PT may be organized differently than in DT. Likely reflecting their cell-specific organization, regulation, and function, these studies indicate the different renal cell types express distinct Ank3 spliceoforms." @default.
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• W1755276168 date "1998-01-01" @default.
• W1755276168 modified "2023-09-25" @default.
• W1755276168 title "Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules" @default.
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• W1755276168 doi "https://doi.org/10.1152/ajprenal.1998.274.1.f129" @default.
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