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- W175542011 abstract "Glargine is a new human synthetic insulin analogue produced by recombinant DNA technology utilizing E.Coli. It differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the B-chain terminus. Glargine is a clear aqueous solution in 100U/ml vials with pH=4 until injected subcutaneously. The interaction of the acidic insulin and the relatively neutral pH of the subcutaneous tissues forms micro-precipitates, and has a relatively constant systemic absorption profile. The formation of micro-precipitates and slow absorption are dependant on the acidity of glargine, hence glargine cannot be mixed or diluted." @default.
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- W175542011 date "2005-01-01" @default.
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- W175542011 title "Update on insulin glargine use in diabetic cats" @default.
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