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- W1755551634 startingPage "1076" @default.
- W1755551634 abstract "We systematically studied the expression of more than fifty histone and DNA (de)methylating enzymes in lymphoma and healthy controls. As a main result, we found that the expression levels of nearly all enzymes become markedly disturbed in lymphoma, suggesting deregulation of large parts of the epigenetic machinery. We discuss the effect of DNA promoter methylation and of transcriptional activity in the context of mutated epigenetic modifiers such as EZH2 and MLL2. As another mechanism, we studied the coupling between the energy metabolism and epigenetics via metabolites that act as cofactors of JmjC-type demethylases. Our study results suggest that Burkitt’s lymphoma and diffuse large B-cell Lymphoma differ by an imbalance of repressive and poised promoters, which is governed predominantly by the activity of methyltransferases and the underrepresentation of demethylases in this regulation. The data further suggest that coupling of epigenetics with the energy metabolism can also be an important factor in lymphomagenesis in the absence of direct mutations of genes in metabolic pathways. Understanding of epigenetic deregulation in lymphoma and possibly in cancers in general must go beyond simple schemes using only a few modes of regulation." @default.
- W1755551634 created "2016-06-24" @default.
- W1755551634 creator A5013508373 @default.
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- W1755551634 creator A5045754538 @default.
- W1755551634 creator A5052114174 @default.
- W1755551634 creator A5063520789 @default.
- W1755551634 date "2015-10-21" @default.
- W1755551634 modified "2023-09-25" @default.
- W1755551634 title "Epigenetic Heterogeneity of B-Cell Lymphoma: Chromatin Modifiers" @default.
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