Matches in SemOpenAlex for { <https://semopenalex.org/work/W1755604815> ?p ?o ?g. }
- W1755604815 endingPage "10" @default.
- W1755604815 startingPage "1" @default.
- W1755604815 abstract "Objectives . HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. We reviewed the current knowledge on HER2 status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss the possible pathogenetic and prognostic roles of HER2 overexpression in GC. Results . HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia (HG-IEN), with higher frequency in gastric type dysplasia. HER2 overexpression was significantly associated with disease recurrence and poor prognosis in EGC representing an independent risk factor for lymph node metastases. HER2 overexpression was more frequent in AGC characterized by high grade, advanced stage, and high Ki-67 labeling index. The discordance in HER2 status was evidenced between primitive GC and synchronous or metachronous metastases. Conclusions . HER2 overexpression in premalignant gastric lesions suggests its potential involvement in the early steps of gastric carcinogenesis. The assessment of HER2 status in EGC may be helpful for the identification of patients who are at low risk for developing nodal metastases. Finally, the possible discordance in HER2 status between primary GC and its synchronous metastases support routine assessment of HER2 both in the primary GC and in its metastatic lesions." @default.
- W1755604815 created "2016-06-24" @default.
- W1755604815 creator A5042484828 @default.
- W1755604815 creator A5052518395 @default.
- W1755604815 creator A5053577755 @default.
- W1755604815 creator A5057940142 @default.
- W1755604815 creator A5058700206 @default.
- W1755604815 date "2015-01-01" @default.
- W1755604815 modified "2023-10-17" @default.
- W1755604815 title "HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach" @default.
- W1755604815 cites W1486586988 @default.
- W1755604815 cites W1499227911 @default.
- W1755604815 cites W1517038934 @default.
- W1755604815 cites W1544851750 @default.
- W1755604815 cites W1807105923 @default.
- W1755604815 cites W187748642 @default.
- W1755604815 cites W1883934427 @default.
- W1755604815 cites W189063294 @default.
- W1755604815 cites W1915522638 @default.
- W1755604815 cites W1945181719 @default.
- W1755604815 cites W1969015681 @default.
- W1755604815 cites W1970590593 @default.
- W1755604815 cites W1971290010 @default.
- W1755604815 cites W1972365331 @default.
- W1755604815 cites W1974940069 @default.
- W1755604815 cites W1981160615 @default.
- W1755604815 cites W1984234287 @default.
- W1755604815 cites W1984874981 @default.
- W1755604815 cites W1987009448 @default.
- W1755604815 cites W1987520359 @default.
- W1755604815 cites W1991691118 @default.
- W1755604815 cites W1996452689 @default.
- W1755604815 cites W1997447221 @default.
- W1755604815 cites W1998758456 @default.
- W1755604815 cites W2002215779 @default.
- W1755604815 cites W2006667358 @default.
- W1755604815 cites W2014064969 @default.
- W1755604815 cites W2014312052 @default.
- W1755604815 cites W2015918488 @default.
- W1755604815 cites W2016178309 @default.
- W1755604815 cites W2016207291 @default.
- W1755604815 cites W2016283072 @default.
- W1755604815 cites W2016469173 @default.
- W1755604815 cites W2017176432 @default.
- W1755604815 cites W2017500327 @default.
- W1755604815 cites W2018173105 @default.
- W1755604815 cites W2020404157 @default.
- W1755604815 cites W2023403447 @default.
- W1755604815 cites W2024204276 @default.
- W1755604815 cites W2026860891 @default.
- W1755604815 cites W2027363118 @default.
- W1755604815 cites W2028153418 @default.
- W1755604815 cites W2031755079 @default.
- W1755604815 cites W2035660792 @default.
- W1755604815 cites W2035753429 @default.
- W1755604815 cites W2039989489 @default.
- W1755604815 cites W2042471142 @default.
- W1755604815 cites W2044513926 @default.
- W1755604815 cites W2051517159 @default.
- W1755604815 cites W2053797805 @default.
- W1755604815 cites W2055671617 @default.
- W1755604815 cites W2055885966 @default.
- W1755604815 cites W2060212546 @default.
- W1755604815 cites W2069430564 @default.
- W1755604815 cites W2071416889 @default.
- W1755604815 cites W2073809314 @default.
- W1755604815 cites W2074488907 @default.
- W1755604815 cites W2075657881 @default.
- W1755604815 cites W2078411266 @default.
- W1755604815 cites W2079864238 @default.
- W1755604815 cites W2079975579 @default.
- W1755604815 cites W2081198849 @default.
- W1755604815 cites W2085163422 @default.
- W1755604815 cites W2088378462 @default.
- W1755604815 cites W2097988373 @default.
- W1755604815 cites W2098881779 @default.
- W1755604815 cites W2099117820 @default.
- W1755604815 cites W2099421298 @default.
- W1755604815 cites W2100439220 @default.
- W1755604815 cites W2104694188 @default.
- W1755604815 cites W2105730286 @default.
- W1755604815 cites W2110831523 @default.
- W1755604815 cites W2112110391 @default.
- W1755604815 cites W2113233663 @default.
- W1755604815 cites W2115927618 @default.
- W1755604815 cites W2119294638 @default.
- W1755604815 cites W2122804643 @default.
- W1755604815 cites W2125677057 @default.
- W1755604815 cites W2126324838 @default.
- W1755604815 cites W2126547130 @default.
- W1755604815 cites W2129148551 @default.
- W1755604815 cites W2129643541 @default.
- W1755604815 cites W2130884130 @default.
- W1755604815 cites W2131774259 @default.
- W1755604815 cites W2132065448 @default.
- W1755604815 cites W2132611552 @default.
- W1755604815 cites W2133422040 @default.
- W1755604815 cites W2136701318 @default.