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• W1755732016 abstract "Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. Such slow kinetics during cell division might reflect a unique cell cycle transit of HSCs that could be critical for maintenance of the indispensable HSC pool and explain the observed loss of engraftment capacity of dividing cells in bone marrow populations enriched for HSCs.Recent studies have suggested that HSCs might possess a much broader differentiation potential but in most cases the reported efficiency of such developmental plasticity has been rather low. We demonstrate that HSCs efficiently engraft within the infarcted myocardium following transplantation. However, engraftment is transitory and hematopoietic in nature. Our findings challenge the experimental basis for ongoing extensive clinical bone marrow transplantation trials of myocardial infarction patients, as these trials were largely initiated on the assumption that HSCs could generate high levels of cardiomyocytes through transdifferentiation. In contrast, low frequency HSC-derived cardiomyocytes were observed outside the infarcted myocardium, but were exclusively derived through cell fusion. Although such heterotypic cell fusion with hematopoietic cells and cardiomyocytes, Purkinje neurons, skeletal muscle and hepatocytes could be detected following injury induction of adult mice it did not occur in steady state tissues. On the other hand during fetal development lymphocyte-derived hepatocytes and Purkinje neurons demonstrate for the first time that the hematopoietic system might contribute toward non-hematopoietic cell lineages through fusion during normal fetal development." @default.
• W1755732016 created "2016-06-24" @default.
• W1755732016 creator A5050236921 @default.
• W1755732016 date "2005-01-01" @default.
• W1755732016 modified "2023-09-22" @default.
• W1755732016 title "Identification of Unique Hematopoietic Stem Cell Properties" @default.
• W1755732016 cites W108816917 @default.
• W1755732016 cites W126539919 @default.
• W1755732016 cites W1441409552 @default.
• W1755732016 cites W1483167997 @default.
• W1755732016 cites W1486751683 @default.
• W1755732016 cites W1511525349 @default.
• W1755732016 cites W151805421 @default.
• W1755732016 cites W1520676690 @default.
• W1755732016 cites W1530543461 @default.
• W1755732016 cites W153436937 @default.
• W1755732016 cites W1542326554 @default.
• W1755732016 cites W1554322234 @default.
• W1755732016 cites W1561399318 @default.
• W1755732016 cites W1561424887 @default.
• W1755732016 cites W1574902133 @default.
• W1755732016 cites W1587502583 @default.
• W1755732016 cites W1617267715 @default.
• W1755732016 cites W1621991227 @default.
• W1755732016 cites W1631250427 @default.
• W1755732016 cites W1631782483 @default.
• W1755732016 cites W171030480 @default.
• W1755732016 cites W173907651 @default.
• W1755732016 cites W17762645 @default.
• W1755732016 cites W1809073012 @default.
• W1755732016 cites W1816761971 @default.
• W1755732016 cites W1836124358 @default.
• W1755732016 cites W1838336174 @default.
• W1755732016 cites W185287585 @default.
• W1755732016 cites W1863063793 @default.
• W1755732016 cites W1905836649 @default.
• W1755732016 cites W1968541478 @default.
• W1755732016 cites W1969219224 @default.
• W1755732016 cites W1970895440 @default.
• W1755732016 cites W1972044265 @default.
• W1755732016 cites W1972736348 @default.
• W1755732016 cites W1973035870 @default.
• W1755732016 cites W1973082669 @default.
• W1755732016 cites W1973278012 @default.
• W1755732016 cites W1973879435 @default.
• W1755732016 cites W1974391793 @default.
• W1755732016 cites W1975025595 @default.
• W1755732016 cites W1975277850 @default.
• W1755732016 cites W1976221714 @default.
• W1755732016 cites W1976895035 @default.
• W1755732016 cites W1977437881 @default.
• W1755732016 cites W1977532338 @default.
• W1755732016 cites W1980867815 @default.
• W1755732016 cites W1982022033 @default.
• W1755732016 cites W1982130774 @default.
• W1755732016 cites W1982337820 @default.
• W1755732016 cites W1982860140 @default.
• W1755732016 cites W1982961252 @default.
• W1755732016 cites W1984270581 @default.
• W1755732016 cites W1984779201 @default.
• W1755732016 cites W1985128235 @default.
• W1755732016 cites W1985395658 @default.
• W1755732016 cites W1986130046 @default.
• W1755732016 cites W1988055260 @default.
• W1755732016 cites W1991227964 @default.
• W1755732016 cites W1991248271 @default.
• W1755732016 cites W1991374176 @default.
• W1755732016 cites W1992396018 @default.
• W1755732016 cites W1992850125 @default.
• W1755732016 cites W1993902386 @default.
• W1755732016 cites W1995286997 @default.
• W1755732016 cites W1995401053 @default.
• W1755732016 cites W1997936907 @default.
• W1755732016 cites W1998566378 @default.
• W1755732016 cites W1999009002 @default.
• W1755732016 cites W2000108021 @default.
• W1755732016 cites W2000156766 @default.
• W1755732016 cites W2001675896 @default.
• W1755732016 cites W2001823825 @default.
• W1755732016 cites W2003652884 @default.
• W1755732016 cites W2004421565 @default.
• W1755732016 cites W2005488930 @default.
• W1755732016 cites W2005675957 @default.
• W1755732016 cites W2007593927 @default.
• W1755732016 cites W2009482935 @default.
• W1755732016 cites W2009804949 @default.
• W1755732016 cites W2010743730 @default.
• W1755732016 cites W2011168429 @default.
• W1755732016 cites W2011221227 @default.
• W1755732016 cites W2012408304 @default.
• W1755732016 cites W2012866178 @default.
• W1755732016 cites W2012890384 @default.
• W1755732016 cites W2012962381 @default.
• W1755732016 cites W2013621644 @default.
• W1755732016 cites W2015495840 @default.
• W1755732016 cites W2015524565 @default.
• W1755732016 cites W2016823790 @default.
• W1755732016 cites W2017446921 @default.
• W1755732016 cites W2018054628 @default.
• W1755732016 cites W2018139282 @default.

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