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- W175579013 abstract "Objective: Many previous studies conducted about the levels ofC-reactive protein (CRP) in patients with ajor depression presentedcontradictory results which ight be a result of limitations inmeasurement of serum levels of CRP. However,even minoralterations of CRP levels can be determined with using recentlydeveloped high sensitive CRP (hs-CRP) measurement method. Tillnow, there have not been any studies investigating for CRP levels inmajor depressive patients using hs-CRP method. The aim of this studywas to determine serum hs-CRP levels in patients with majordepression who were treated with various antidepressants and tocompare with those of healthy controls.Methods: Twenty-three patients who are diagnosed clinically asmajor depression and 26 healthy controls were included in this study.The severity of the depression was quantified with 17-item HamiltonDepression Rating Scale (HAM-D). Serum hs-CRP levels weremeasured before and after antidepressant treatment of eight weeks.Results: Serum hs-CRP levels were found as 0.75 ± 0.34 mg/dl and0.76 ± 0.48 mg/dl before and after treatment respectively in majordepression group. The difference was not statistically significantaccording to paired samples T test (p>0.05). The level of healthygroup was 0.71 ± 0.49 mg/dl and the difference between controlgroup and major depression group was also insignificant (p>0.05).Discussion: The results of this study showed that serum CRP levels inmajor depressive patients as measured with hs-CRP measurementmethod ? a 30 fold ore sensitive method for CRP serum levels than themethods used in previous studies-do not show any significantdifferences from healthy control group and do not change in quantitywith various antidepressant treatments." @default.
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- W175579013 date "2004-01-01" @default.
- W175579013 modified "2023-09-27" @default.
- W175579013 title "The relationship between high sensitive C-Reactive proteinlevels and treatment response in patients withmajor depression" @default.
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