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• W1755849265 endingPage "86" @default.
• W1755849265 startingPage "39" @default.
• W1755849265 abstract "Cell activation results from the transient displacement of an active balance between positive and negative signaling. This displacement depends in part on the engagement of cell surface receptors by extracellular ligands. Among these are receptors for the Fc portion of immunoglobulins (FcRs). FcRs are widely expressed by cells of hematopoietic origin. When binding antibodies, FcRs provide these cells with immunoreceptors capable of triggering numerous biological responses in response to a specific antigen. FcR‐dependent cell activation is regulated by negative signals which are generated together with positive signals within signalosomes that form upon FcR engagement. Many molecules involved in positive signaling, including the FcRβ subunit, the src kinase lyn, the cytosolic adapter Grb2, and the transmembrane adapters LAT and NTAL, are indeed also involved in negative signaling. A major player in negative regulation of FcR signaling is the inositol 5‐phosphatase SHIP1. Several layers of negative regulation operate sequentially as FcRs are engaged by extracellular ligands with an increasing valency. A background protein tyrosine phosphatase‐dependent negative regulation maintains cells in a «resting» state. SHIP1‐dependent negative regulation can be detected as soon as high‐affinity FcRs are occupied by antibodies in the absence of antigen. It increases when activating FcRs are engaged by multivalent ligands and, further, when FcR aggregation increases, accounting for the bell‐shaped dose‐response curve observed in excess of ligand. Finally, F‐actin skeleton‐associated high‐molecular weight SHIP1, recruited to phosphorylated ITIMs, concentrates in signaling complexes when activating FcRs are coengaged with inhibitory FcRs by immune complexes. Based on these data, activating and inhibitory FcRs could be used for new therapeutic approaches to immune disorders." @default.
• W1755849265 created "2016-06-24" @default.
• W1755849265 creator A5018921593 @default.
• W1755849265 creator A5023005855 @default.
• W1755849265 date "2006-01-01" @default.
• W1755849265 modified "2023-10-13" @default.
• W1755849265 title "Negative Signaling in Fc Receptor Complexes" @default.
• W1755849265 cites W1481671615 @default.
• W1755849265 cites W1489188266 @default.
• W1755849265 cites W1501023121 @default.
• W1755849265 cites W1503718503 @default.
• W1755849265 cites W1505084152 @default.
• W1755849265 cites W1505599659 @default.
• W1755849265 cites W1509846900 @default.
• W1755849265 cites W1517466201 @default.
• W1755849265 cites W1519260014 @default.
• W1755849265 cites W1521040393 @default.
• W1755849265 cites W1539771287 @default.
• W1755849265 cites W1543701418 @default.
• W1755849265 cites W1544832651 @default.
• W1755849265 cites W1548747789 @default.
• W1755849265 cites W1553517909 @default.
• W1755849265 cites W1564132479 @default.
• W1755849265 cites W1598460215 @default.
• W1755849265 cites W1599249369 @default.
• W1755849265 cites W1600690281 @default.
• W1755849265 cites W1616088220 @default.
• W1755849265 cites W1646874273 @default.
• W1755849265 cites W1649636482 @default.
• W1755849265 cites W1654498070 @default.
• W1755849265 cites W1669895089 @default.
• W1755849265 cites W1693076983 @default.
• W1755849265 cites W1728407419 @default.
• W1755849265 cites W1797401437 @default.
• W1755849265 cites W1804861156 @default.
• W1755849265 cites W1886292263 @default.
• W1755849265 cites W1892347675 @default.
• W1755849265 cites W1903287340 @default.
• W1755849265 cites W1918293056 @default.
• W1755849265 cites W1925024750 @default.
• W1755849265 cites W1948970254 @default.
• W1755849265 cites W1964180982 @default.
• W1755849265 cites W1965053438 @default.
• W1755849265 cites W1965711974 @default.
• W1755849265 cites W1971231646 @default.
• W1755849265 cites W1972145067 @default.
• W1755849265 cites W1972395912 @default.
• W1755849265 cites W1972910214 @default.
• W1755849265 cites W1975987716 @default.
• W1755849265 cites W1976805459 @default.
• W1755849265 cites W1977619443 @default.
• W1755849265 cites W1978531552 @default.
• W1755849265 cites W1979297102 @default.
• W1755849265 cites W1980388991 @default.
• W1755849265 cites W1981431542 @default.
• W1755849265 cites W1981906697 @default.
• W1755849265 cites W1982833418 @default.
• W1755849265 cites W1983840607 @default.
• W1755849265 cites W1983940041 @default.
• W1755849265 cites W1985748428 @default.
• W1755849265 cites W1985782864 @default.
• W1755849265 cites W1986542865 @default.
• W1755849265 cites W1987583044 @default.
• W1755849265 cites W1990623556 @default.
• W1755849265 cites W1991661989 @default.
• W1755849265 cites W1996447998 @default.
• W1755849265 cites W1999447682 @default.
• W1755849265 cites W2000061036 @default.
• W1755849265 cites W2004756723 @default.
• W1755849265 cites W2006249265 @default.
• W1755849265 cites W2006506188 @default.
• W1755849265 cites W2007124301 @default.
• W1755849265 cites W2008232890 @default.
• W1755849265 cites W2008969896 @default.
• W1755849265 cites W2011197811 @default.
• W1755849265 cites W2011443550 @default.
• W1755849265 cites W2011870840 @default.
• W1755849265 cites W2012608489 @default.
• W1755849265 cites W2014148669 @default.
• W1755849265 cites W2015409726 @default.
• W1755849265 cites W2016098968 @default.
• W1755849265 cites W2018259266 @default.
• W1755849265 cites W2018826402 @default.
• W1755849265 cites W2020260110 @default.
• W1755849265 cites W2021211941 @default.
• W1755849265 cites W2022298704 @default.
• W1755849265 cites W2022697474 @default.
• W1755849265 cites W2022864842 @default.
• W1755849265 cites W2024203551 @default.
• W1755849265 cites W2025854364 @default.
• W1755849265 cites W2029735500 @default.
• W1755849265 cites W2032346440 @default.
• W1755849265 cites W2034068956 @default.
• W1755849265 cites W2038012326 @default.
• W1755849265 cites W2039490597 @default.
• W1755849265 cites W2039634043 @default.
• W1755849265 cites W2042209841 @default.
• W1755849265 cites W2042797177 @default.

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