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• W1755973668 abstract "Domestication and subsequent selective pressures have produced a large variety of pig coat colors in different regions and breeds. The melanocortin 1 receptor (MC1R) gene plays a crucial role in determining coat color of mammals. Here, we investigated genetic diversity and selection at the coding region of the porcine melanocortin receptor 1 (MC1R) in Tibetan pigs and Landrace pigs. By contrast, genetic variability was much lower in Landrace pigs than in Tibetan pigs. Meanwhile, haplotype analysis showed that Tibetan pigs possessed shared haplotypes, suggesting a possibility of recent introgression event by way of crossbreeding with neighboring domestic pigs or shared ancestral polymorphism. Additionally, we detected positive selection at the MC1R in both Tibetan pigs and Landrace pigs through the dN/dS analysis. These findings suggested that novel phenotypic change (dark coat color) caused by novel mutations may help Tibetan pigs against intensive solar ultraviolet (UV) radiation and camouflage in wild environment, whereas white coat color in Landrace were intentionally selected by human after domestication. Furthermore, both the phylogenetic analysis and the network analysis provided clues that MC1R in Asian and European wild boars may have initially experienced different selective pressures, and MC1R alleles diversified in modern domesticated pigs." @default.
• W1755973668 created "2016-06-24" @default.
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• W1755973668 date "2016-01-01" @default.
• W1755973668 modified "2023-09-27" @default.
• W1755973668 title "Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 ( MC1R ) gene in Tibetan pigs and Landrace pigs" @default.
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• W1755973668 doi "https://doi.org/10.1016/j.gene.2015.09.032" @default.
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• W1755973668 hasPublicationYear "2016" @default.
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