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• W1756471183 abstract "In the last decade, pediatric cardiologists have witnessed a revolution in the knowledge of the pathophysiology of rare arrhythmias. The identification of the molecular basis of several hereditary arrhythmia syndromes has been instrumental in this development. Within 12 years the number of causal genes has increased from two in 1995 to at least 24 early 2007 ( Table I ). Based on this knowledge, established treatment strategies in the 1990s have been modified during the most recent years. This leads to timely and tailored treatment of (asymptomatic) gene carriers, both through personalized lifestyle advices and pharmacologically. At the same time and of equal importance, unaffected family members (noncarriers) can be reassured. Number of Identified Genes Causal to Inherited Arrhythmia Syndromes in 1995 and Early 2007 1995 2007 Long QT syndrome(s) 2 10 Short QT syndrome – 3 ST elevation right precordium, “RBBB,” SCD – 4 Catecholamine‐induced PMVT/VF – 3 Short‐coupled Torsades de Pointes – – Isolated conduction disorders (AVN, BB) – 1 Sinus node disease, atrial standstill – 2" @default.
• W1756471183 created "2016-06-24" @default.
• W1756471183 creator A5063961975 @default.
• W1756471183 date "2008-01-22" @default.
• W1756471183 modified "2023-10-16" @default.
• W1756471183 title "Channelopathies in Children and Adults" @default.
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• W1756471183 doi "https://doi.org/10.1111/j.1540-8159.2008.00955.x" @default.
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