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- W1757014779 abstract "Purpose To investigate the use of non‐Gaussian diffusion‐weighted imaging (q‐space imaging [QSI]) to estimate diurnal changes in intervertebral disc (IVD) microstructure. Materials and Methods IVDs of 15 male subjects (mean age, 27.3 years; mean body mass index, 22.50 kg/m 2 ) were investigated once in the morning, less than 30 min after rising, and a second time in the evening after at least 10 h of normal physical activity, using 3 Tesla (T) MR imaging. T2 mapping and QSI data values (apparent diffusion coefficient [ADC], root mean square displacement [RMSD], and apparent kurtosis coefficient [AKC]) were calculated and compared between the morning and evening imaging sessions. Results The T2, ADC, and RMSD values showed a significant decrease in the evening (175.8 ± 49.5 ms, 1.56 ± 0.32 10 −3 mm 2 /s and 40.0 ± 3.0 μm, respectively; P < 0.05 for all values; paired t‐test), when compared with the morning values (226.5 ± 83.8 ms, 1.69 ± 0.29 10 −3 mm 2 /s and 45.2 ± 2.9 μm, respectively). The AKC value showed a significant increase in the evening (0.67 ± 0.08), when compared with the morning value (0.58 ± 0.04; P < 0.05). Conclusion The RMSD and AKC values obtained from QSI analysis may be biomarkers for IVD diurnal microstructural changes. J. Magn. Reson. Imaging 2014;40:1208–1214 . © 2013 Wiley Periodicals, Inc ." @default.
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- W1757014779 date "2013-11-19" @default.
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- W1757014779 title "Non-gaussian diffusion-weighted imaging for assessing diurnal changes in intervertebral disc microstructure" @default.
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- W1757014779 doi "https://doi.org/10.1002/jmri.24459" @default.
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