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• W1757080911 abstract "The cardiac hormone, B-type natriuretic peptide (BNP), is one of human natriuretic peptides which possesses cardiorenal protective actions and is used as a therapeutic and a biomarker for heart failure (HF). Its prohormone, proBNP1_108, is processed by the proNPs convertases, corin or furin, to inactive NT-proBNP1_76 and active BNP1-32. Paradoxically, circulating NT-proBNP and BNP are elevated in HF leading to the use of BNP as a sensitive and predictive marker of HF. This paradox may be explained by the nonspecific nature of conventional assays and/or a relative deficiency state of active BNP as characterized by an increase in inactive proBNP_108 and a decrease in active BNP1-32. Therefore, understanding the regulation of proBNP1_108 processing and the role of the convertase corin may be important in understanding the physiology of HF. Corin is expressed in heart and kidney and may play an important role in regulating blood pressure and remodeling of the heart. The processing of proBNP1_108 by corin may be controlled by O-linked glycosylation of proBNP1-108. A potential impairment of proBNP1lo8 processing in HF may be linked to dysregulation of the convertase corin, which may offer therapeutic opportunities to control proBNPlo0s processing and its activation in HF." @default.
• W1757080911 created "2016-06-24" @default.
• W1757080911 creator A5014193048 @default.
• W1757080911 creator A5022842746 @default.
• W1757080911 creator A5074323945 @default.
• W1757080911 date "2013-01-01" @default.
• W1757080911 modified "2023-09-27" @default.
• W1757080911 title "BNP Molecular Forms and Processing by the Cardiac Serine Protease Corin" @default.
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• W1757080911 doi "https://doi.org/10.1016/b978-0-12-407680-8.00001-4" @default.
• W1757080911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4522930" @default.
• W1757080911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24015598" @default.
• W1757080911 hasPublicationYear "2013" @default.
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