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- W1757280304 abstract "Caveolin-1 (Cav-1) is an important signalling scaffold protein involved in smooth muscle contraction; however, the role of Cav-1 in airway responsiveness has not been elucidated so far. Our aim was to determine the relation of Cav-1 expression with airway hyperresponsiveness (AHR) in a guinea pig asthma model. To evaluate this relation, three inhaled antigenic challenges were applied every 10 days to antigen (ovalbumin; OVA) sensitized guinea pigs (n=9). Antigen-induced airway obstruction, AHR to histamine, and the expression of Cav-1 in lung and airway smooth muscle cells (ASMC), was evaluated at the third OVA challenge. The control group received saline solution instead of OVA (n=6). From the first challenge on, OVA induced a transient airway obstruction and the development of AHR at the third antigenic challenge. Cav-1 mRNA levels in lung (assessed by RT-PCR) significantly decreased in our asthma model compared with the control group (P" @default.
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- W1757280304 date "2011-09-01" @default.
- W1757280304 modified "2023-10-01" @default.
- W1757280304 title "Caveolin-1 expression in airway smooth muscle cells is related to airway responsiveness magnitude in allergic asthma model" @default.
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