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• W1757322900 endingPage "1856" @default.
• W1757322900 startingPage "1848" @default.
• W1757322900 abstract "With each heartbeat, Connexin43 (Cx43) cell–cell communication gap junctions are needed to rapidly spread and coordinate excitation signals for an effective heart contraction. The correct formation and delivery of channels to their respective membrane subdomain is referred to as protein trafficking. Altered Cx43 trafficking is a dangerous complication of diseased myocardium which contributes to the arrhythmias of sudden cardiac death. Cx43 has also been found to regulate many other cellular processes that cannot be explained by cell–cell communication. We recently identified the existence of up to six endogenous internally translated Cx43 N-terminal truncated isoforms from the same full-length mRNA molecule. This is the first evidence that alternative translation is possible for human ion channels and in human heart. Interestingly, we found that these internally translated isoforms, more specifically the 20 kDa isoform (GJA1-20k), is important for delivery of Cx43 to its respective membrane subdomain. This review covers recent advances in Cx43 trafficking and potential importance of alternatively translated Cx43 truncated isoforms. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. • Forward trafficking of Cx43 follows a Targeted Delivery model of being directed from Golgi to the intercalated disc. • Alternatively translated truncated isoforms of Cx43, in particular GJA1-20k, aid in trafficking of full length protein. • Non-canonical roles of the Cx43 C-terminus may be secondary to smaller alternatively translated isoforms of the same mRNA." @default.
• W1757322900 created "2016-06-24" @default.
• W1757322900 creator A5017223962 @default.
• W1757322900 creator A5055364923 @default.
• W1757322900 date "2016-07-01" @default.
• W1757322900 modified "2023-09-29" @default.
• W1757322900 title "The “tail” of Connexin43: An unexpected journey from alternative translation to trafficking" @default.
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