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- W175764694 abstract "In the studies presented, the relative extent of tyramine (TYR) deamination to p-hydroxyphenylacidic acid (HPAA) and of TYR conjugation was determined before and during treatment with 5 different MAO inhibitor (MAOI) drugs. Healthy ambulatory subjects were treated p.o. for 2 – 4 weeks. Data were evaluated from (n) subjects. MAOI drugs were: Brofaromine (Brof): 100 – 150 mg/d (9); clorgyline (Clor): 5, 10, 15 mg/d (3); selegiline (Sel): 5, 20 mg/d (6); tranylcypromine (TCP): 20 mg/d (4) and phenelzine (Phen): 30, 45 mg/d (l). After oral doses of TYR causing systolic blood pressure (BP) increases of 30 mm Hg, plasma concentrations of HPAA, conjugated (conj) TYR (after enzymatic deconjugation) and of unconjugated (unc) TYR were determined by HPLC. The area under the plasma level-time curve (AUC) was calculated considering the different TYR doses given (AUCspec). The following results were obtained: The results suggest that during inhibition of deamination in the gastrointestinal tract, inactivation by conjugation protects the organism against the pharmacological action of the symphatomimetic amine tyramine." @default.
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- W175764694 date "1988-01-01" @default.
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- W175764694 title "Metabolism of Tyramine on Subjects Treated with Different Monoamine Oxidase Inhibitors" @default.
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- W175764694 doi "https://doi.org/10.1007/978-1-4612-4602-2_39" @default.
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