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- W175791812 abstract "Publisher Summary This chapter discusses the role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia. The chapter examines the relationship between alterations in the mechanosensitive properties of pelvic nerve afferent fibers innervating the colon and the facilitated VMR to distension following instillation of zymosan into the colon. A significant finding of the present study was the absence of correspondence between the duration of afferent fiber sensitization and visceral hyperalgesia. Several studies have investigated the effect of experimental inflammation of the colon or bladder on mechanosensitive pelvic nerve afferent fibers. Maintenance of hyperalgesia may not require persistent sensitization, but only enhanced or episodic increases in spontaneous input. Spontaneous activity was increased in the present experiments, significantly at times early after intracolonic instillation of zymosan, and modestly at 3 h. Input from silent afferents could also be important to maintenance of hyperalgesia. Arguments opposing a role for sustained peripheral input as necessary to the maintenance of hyperalgesia are given. There are clear and long-lasting central nervous system consequences and contributions to the maintenance of hyperalgesia and resolution of the relative roles of peripheral and central mechanisms awaits experimental study." @default.
- W175791812 created "2016-06-24" @default.
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- W175791812 date "2000-01-01" @default.
- W175791812 modified "2023-09-27" @default.
- W175791812 title "Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia" @default.
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- W175791812 doi "https://doi.org/10.1016/s0079-6123(00)29029-8" @default.
- W175791812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11098705" @default.
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