Matches in SemOpenAlex for { <https://semopenalex.org/work/W1758236490> ?p ?o ?g. }
- W1758236490 endingPage "7245" @default.
- W1758236490 startingPage "7240" @default.
- W1758236490 abstract "We have evaluated the effects of anti-TNF-alpha, anti-IL-1, and combined anti-TNF-alpha/anti-CD4 therapy in collagen-induced arthritis. Blockade of TNF-alpha or IL-1 before disease onset delayed, but did not prevent, the induction of arthritis. When treatment was initiated after onset of arthritis, anti-TNF-alpha, anti-IL-1beta, and anti-IL-1R (which blocks IL-1alpha and IL-1beta) were all found to be effective in reducing the severity of arthritis, with anti-IL-1R and anti-IL-1beta showing greater efficacy than anti-TNF-alpha. Anti-IL-1beta was equally as effective as anti-IL-1R, indicating that IL-1beta plays a more prominent role than IL-1alpha in collagen-induced arthritis. An additive effect was observed between anti-TNF-alpha and anti-IL-1R in the prevention of joint erosion and in normalization of the levels of serum amyloid P. Combined anti-TNF-alpha/anti-CD4 therapy also caused normalization of serum amyloid P levels. The therapeutic effect of anti-TNF-alpha plus anti-CD4 was comparable to that of anti-TNF-alpha plus anti-IL-1R, suggesting that combined anti-TNF-alpha/anti-CD4 therapy prevents both TNF-alpha- and IL-1-mediated pathology. Anti-TNF-alpha treatment reduced IL-1beta expression in the joint and, conversely, anti-IL-1beta treatment reduced TNF-alpha expression. Combined anti-TNF-alpha/anti-CD4 treatment almost completely blocked the expression of IL-1beta, thereby confirming the ability of this form of combination therapy to prevent IL-1ss-mediated pathology." @default.
- W1758236490 created "2016-06-24" @default.
- W1758236490 creator A5049125865 @default.
- W1758236490 creator A5050302517 @default.
- W1758236490 creator A5057580992 @default.
- W1758236490 creator A5063329660 @default.
- W1758236490 date "2000-12-15" @default.
- W1758236490 modified "2023-10-06" @default.
- W1758236490 title "Evaluation of TNF-α and IL-1 Blockade in Collagen-Induced Arthritis and Comparison with Combined Anti-TNF-α/Anti-CD4 Therapy" @default.
- W1758236490 cites W132781887 @default.
- W1758236490 cites W1528765374 @default.
- W1758236490 cites W1968376159 @default.
- W1758236490 cites W1973160392 @default.
- W1758236490 cites W1978103379 @default.
- W1758236490 cites W1982425773 @default.
- W1758236490 cites W1987185635 @default.
- W1758236490 cites W1989832126 @default.
- W1758236490 cites W1990568245 @default.
- W1758236490 cites W2001660220 @default.
- W1758236490 cites W2020250668 @default.
- W1758236490 cites W2026342001 @default.
- W1758236490 cites W2033228977 @default.
- W1758236490 cites W2035274613 @default.
- W1758236490 cites W2043287930 @default.
- W1758236490 cites W2056813079 @default.
- W1758236490 cites W2066397836 @default.
- W1758236490 cites W2070480282 @default.
- W1758236490 cites W2079528410 @default.
- W1758236490 cites W2083721607 @default.
- W1758236490 cites W2085853581 @default.
- W1758236490 cites W2090620423 @default.
- W1758236490 cites W2091409282 @default.
- W1758236490 cites W2110061490 @default.
- W1758236490 cites W2133602875 @default.
- W1758236490 cites W2140537198 @default.
- W1758236490 cites W2142273705 @default.
- W1758236490 cites W2143939606 @default.
- W1758236490 cites W2154746915 @default.
- W1758236490 cites W2167031471 @default.
- W1758236490 cites W2328587823 @default.
- W1758236490 cites W4322703114 @default.
- W1758236490 doi "https://doi.org/10.4049/jimmunol.165.12.7240" @default.
- W1758236490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11120857" @default.
- W1758236490 hasPublicationYear "2000" @default.
- W1758236490 type Work @default.
- W1758236490 sameAs 1758236490 @default.
- W1758236490 citedByCount "112" @default.
- W1758236490 countsByYear W17582364902012 @default.
- W1758236490 countsByYear W17582364902013 @default.
- W1758236490 countsByYear W17582364902014 @default.
- W1758236490 countsByYear W17582364902015 @default.
- W1758236490 countsByYear W17582364902016 @default.
- W1758236490 countsByYear W17582364902017 @default.
- W1758236490 countsByYear W17582364902018 @default.
- W1758236490 countsByYear W17582364902019 @default.
- W1758236490 countsByYear W17582364902020 @default.
- W1758236490 countsByYear W17582364902021 @default.
- W1758236490 countsByYear W17582364902022 @default.
- W1758236490 countsByYear W17582364902023 @default.
- W1758236490 crossrefType "journal-article" @default.
- W1758236490 hasAuthorship W1758236490A5049125865 @default.
- W1758236490 hasAuthorship W1758236490A5050302517 @default.
- W1758236490 hasAuthorship W1758236490A5057580992 @default.
- W1758236490 hasAuthorship W1758236490A5063329660 @default.
- W1758236490 hasBestOaLocation W17582364901 @default.
- W1758236490 hasConcept C126322002 @default.
- W1758236490 hasConcept C134018914 @default.
- W1758236490 hasConcept C141071460 @default.
- W1758236490 hasConcept C170493617 @default.
- W1758236490 hasConcept C17991360 @default.
- W1758236490 hasConcept C203014093 @default.
- W1758236490 hasConcept C2775944032 @default.
- W1758236490 hasConcept C2777077863 @default.
- W1758236490 hasConcept C2777575956 @default.
- W1758236490 hasConcept C2778468042 @default.
- W1758236490 hasConcept C2778690821 @default.
- W1758236490 hasConcept C47348012 @default.
- W1758236490 hasConcept C49453240 @default.
- W1758236490 hasConcept C64943373 @default.
- W1758236490 hasConcept C71924100 @default.
- W1758236490 hasConceptScore W1758236490C126322002 @default.
- W1758236490 hasConceptScore W1758236490C134018914 @default.
- W1758236490 hasConceptScore W1758236490C141071460 @default.
- W1758236490 hasConceptScore W1758236490C170493617 @default.
- W1758236490 hasConceptScore W1758236490C17991360 @default.
- W1758236490 hasConceptScore W1758236490C203014093 @default.
- W1758236490 hasConceptScore W1758236490C2775944032 @default.
- W1758236490 hasConceptScore W1758236490C2777077863 @default.
- W1758236490 hasConceptScore W1758236490C2777575956 @default.
- W1758236490 hasConceptScore W1758236490C2778468042 @default.
- W1758236490 hasConceptScore W1758236490C2778690821 @default.
- W1758236490 hasConceptScore W1758236490C47348012 @default.
- W1758236490 hasConceptScore W1758236490C49453240 @default.
- W1758236490 hasConceptScore W1758236490C64943373 @default.
- W1758236490 hasConceptScore W1758236490C71924100 @default.
- W1758236490 hasIssue "12" @default.
- W1758236490 hasLocation W17582364901 @default.
- W1758236490 hasLocation W17582364902 @default.