FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1758358233> ?p ?o ?g. }

• W1758358233 endingPage "8" @default.
• W1758358233 startingPage "7135" @default.
• W1758358233 abstract "Transforming growth factor B (TGF-beta) is a potent immunosuppressive cytokine that is frequently associated with mechanisms of tumor escape from immunosurveillance. We report that transplantation of murine bone marrow (BM) expressing a dominant-negative TGF-beta type II receptor (TbetaRIIDN) leads to the generation of mature leukocytes capable of a potent antitumor response in vivo. Hematopoietic precursors in murine BM from donor mice were rendered insensitive to TGF-beta via retroviral expression of the TbetaRIIDN construct and were transplanted in C57BL/6 mice before tumor challenge. After i.v. administration of 5 x 10(5) B16-F10 murine melanoma cells into TbetaRIIDN-BM transplanted recipients, survival of challenged mice at 45 days was 70% (7 of 10) versus 0% (0 of 10) for vector-control treated mice, and surviving TbetaRIIDN-BM mice showed a virtual absence of metastatic lesions in the lung. We also investigated the utility of the TGF-beta-targeted approach in a mouse metastatic model of prostate cancer, TRAMP-C2. Treatment of male C57BL/6 mice with TbetaRIIDN-BM resulted in the survival of 80% (4 of 5) of recipients versus 0% (0 of 5) in green fluorescent protein-BM recipients or wild-type controls. Cytolytic T-cell assays indicate that a specific T-cell response against B16-F10 cells was generated in the TbetaRIIDN-BM-treated mice, suggesting that a gene therapy approach to inducing TGF-beta insensitivity in transplanted BM cells may be a potent anticancer therapy." @default.
• W1758358233 created "2016-06-24" @default.
• W1758358233 creator A5002922209 @default.
• W1758358233 creator A5010921273 @default.
• W1758358233 creator A5030411648 @default.
• W1758358233 creator A5040924182 @default.
• W1758358233 creator A5042153999 @default.
• W1758358233 creator A5048628138 @default.
• W1758358233 creator A5052853942 @default.
• W1758358233 creator A5054650087 @default.
• W1758358233 creator A5056828445 @default.
• W1758358233 date "2002-12-15" @default.
• W1758358233 modified "2023-10-12" @default.
• W1758358233 title "Suppression of tumor metastasis by blockade of transforming growth factor beta signaling in bone marrow cells through a retroviral-mediated gene therapy in mice." @default.
• W1758358233 cites W1494836084 @default.
• W1758358233 cites W1907188220 @default.
• W1758358233 cites W1951412780 @default.
• W1758358233 cites W1984146759 @default.
• W1758358233 cites W1992023512 @default.
• W1758358233 cites W1993149812 @default.
• W1758358233 cites W2003918448 @default.
• W1758358233 cites W2006005116 @default.
• W1758358233 cites W2044069347 @default.
• W1758358233 cites W2045428282 @default.
• W1758358233 cites W2058006748 @default.
• W1758358233 cites W2076528339 @default.
• W1758358233 cites W2079517510 @default.
• W1758358233 cites W2129379081 @default.
• W1758358233 cites W2143729842 @default.
• W1758358233 cites W2154086478 @default.
• W1758358233 cites W2165254830 @default.
• W1758358233 cites W2165410229 @default.
• W1758358233 cites W2172077728 @default.
• W1758358233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12499244" @default.
• W1758358233 hasPublicationYear "2002" @default.
• W1758358233 type Work @default.
• W1758358233 sameAs 1758358233 @default.
• W1758358233 citedByCount "22" @default.
• W1758358233 countsByYear W17583582332013 @default.
• W1758358233 countsByYear W17583582332019 @default.
• W1758358233 countsByYear W17583582332021 @default.
• W1758358233 crossrefType "journal-article" @default.
• W1758358233 hasAuthorship W1758358233A5002922209 @default.
• W1758358233 hasAuthorship W1758358233A5010921273 @default.
• W1758358233 hasAuthorship W1758358233A5030411648 @default.
• W1758358233 hasAuthorship W1758358233A5040924182 @default.
• W1758358233 hasAuthorship W1758358233A5042153999 @default.
• W1758358233 hasAuthorship W1758358233A5048628138 @default.
• W1758358233 hasAuthorship W1758358233A5052853942 @default.
• W1758358233 hasAuthorship W1758358233A5054650087 @default.
• W1758358233 hasAuthorship W1758358233A5056828445 @default.
• W1758358233 hasConcept C104317684 @default.
• W1758358233 hasConcept C109159458 @default.
• W1758358233 hasConcept C111599444 @default.
• W1758358233 hasConcept C118131993 @default.
• W1758358233 hasConcept C126322002 @default.
• W1758358233 hasConcept C203014093 @default.
• W1758358233 hasConcept C2778229498 @default.
• W1758358233 hasConcept C2778690821 @default.
• W1758358233 hasConcept C2780007613 @default.
• W1758358233 hasConcept C28328180 @default.
• W1758358233 hasConcept C2911091166 @default.
• W1758358233 hasConcept C502942594 @default.
• W1758358233 hasConcept C55493867 @default.
• W1758358233 hasConcept C71924100 @default.
• W1758358233 hasConcept C86803240 @default.
• W1758358233 hasConcept C95444343 @default.
• W1758358233 hasConceptScore W1758358233C104317684 @default.
• W1758358233 hasConceptScore W1758358233C109159458 @default.
• W1758358233 hasConceptScore W1758358233C111599444 @default.
• W1758358233 hasConceptScore W1758358233C118131993 @default.
• W1758358233 hasConceptScore W1758358233C126322002 @default.
• W1758358233 hasConceptScore W1758358233C203014093 @default.
• W1758358233 hasConceptScore W1758358233C2778229498 @default.
• W1758358233 hasConceptScore W1758358233C2778690821 @default.
• W1758358233 hasConceptScore W1758358233C2780007613 @default.
• W1758358233 hasConceptScore W1758358233C28328180 @default.
• W1758358233 hasConceptScore W1758358233C2911091166 @default.
• W1758358233 hasConceptScore W1758358233C502942594 @default.
• W1758358233 hasConceptScore W1758358233C55493867 @default.
• W1758358233 hasConceptScore W1758358233C71924100 @default.
• W1758358233 hasConceptScore W1758358233C86803240 @default.
• W1758358233 hasConceptScore W1758358233C95444343 @default.
• W1758358233 hasIssue "24" @default.
• W1758358233 hasLocation W17583582331 @default.
• W1758358233 hasOpenAccess W1758358233 @default.
• W1758358233 hasPrimaryLocation W17583582331 @default.
• W1758358233 hasRelatedWork W111202540 @default.
• W1758358233 hasRelatedWork W1966293159 @default.
• W1758358233 hasRelatedWork W1982505164 @default.
• W1758358233 hasRelatedWork W1995436455 @default.
• W1758358233 hasRelatedWork W2077902477 @default.
• W1758358233 hasRelatedWork W2089069954 @default.
• W1758358233 hasRelatedWork W2292563379 @default.
• W1758358233 hasRelatedWork W2412082697 @default.
• W1758358233 hasRelatedWork W2415920961 @default.
• W1758358233 hasRelatedWork W2753217443 @default.
• W1758358233 hasVolume "62" @default.

• next