Matches in SemOpenAlex for { <https://semopenalex.org/work/W1758370979> ?p ?o ?g. }
- W1758370979 endingPage "1790" @default.
- W1758370979 startingPage "1779" @default.
- W1758370979 abstract "FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. In our study, we found a marked reduction of FAM3A expression in the livers of db/db and high-fat diet (HFD)-induced diabetic mice. Hepatic overexpression of FAM3A markedly attenuated hyperglycemia, insulin resistance, and fatty liver with increased Akt (pAkt) signaling and repressed gluconeogenesis and lipogenesis in the livers of those mice. In contrast, small interfering RNA (siRNA)-mediated knockdown of hepatic FAM3A resulted in hyperglycemia with reduced pAkt levels and increased gluconeogenesis and lipogenesis in the livers of C57BL/6 mice. In vitro study revealed that FAM3A was mainly localized in the mitochondria, where it increases adenosine triphosphate (ATP) production and secretion in cultured hepatocytes. FAM3A activated Akt through the p110α catalytic subunit of PI3K in an insulin-independent manner. Blockade of P2 ATP receptors or downstream phospholipase C (PLC) and IP3R and removal of medium calcium all significantly reduced FAM3A-induced increase in cytosolic free Ca2+ levels and attenuated FAM3A-mediated PI3K/Akt activation. Moreover, FAM3A-induced Akt activation was completely abolished by the inhibition of calmodulin (CaM). Conclusion: FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K-Akt signaling pathway by way of a Ca2+/CaM-dependent mechanism. Up-regulating hepatic FAM3A expression may represent an attractive means for the treatment of insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD). (Hepatology 2014;59:1779–1790)" @default.
- W1758370979 created "2016-06-24" @default.
- W1758370979 creator A5004877322 @default.
- W1758370979 creator A5005096673 @default.
- W1758370979 creator A5005296486 @default.
- W1758370979 creator A5010558103 @default.
- W1758370979 creator A5012677271 @default.
- W1758370979 creator A5016423407 @default.
- W1758370979 creator A5017273285 @default.
- W1758370979 creator A5020693684 @default.
- W1758370979 creator A5021636467 @default.
- W1758370979 creator A5034012227 @default.
- W1758370979 creator A5038734047 @default.
- W1758370979 creator A5047237529 @default.
- W1758370979 creator A5051605432 @default.
- W1758370979 creator A5052925180 @default.
- W1758370979 creator A5070911765 @default.
- W1758370979 creator A5078335465 @default.
- W1758370979 creator A5089069771 @default.
- W1758370979 creator A5090499433 @default.
- W1758370979 creator A5090935475 @default.
- W1758370979 date "2014-03-27" @default.
- W1758370979 modified "2023-10-17" @default.
- W1758370979 title "FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis" @default.
- W1758370979 cites W1968572179 @default.
- W1758370979 cites W1971552691 @default.
- W1758370979 cites W1978113489 @default.
- W1758370979 cites W1982559554 @default.
- W1758370979 cites W1982810858 @default.
- W1758370979 cites W1989007214 @default.
- W1758370979 cites W2005847430 @default.
- W1758370979 cites W2017216401 @default.
- W1758370979 cites W2020344975 @default.
- W1758370979 cites W2020931980 @default.
- W1758370979 cites W2029017812 @default.
- W1758370979 cites W2053761204 @default.
- W1758370979 cites W2059996601 @default.
- W1758370979 cites W2067917251 @default.
- W1758370979 cites W2071749236 @default.
- W1758370979 cites W2073020813 @default.
- W1758370979 cites W2081347924 @default.
- W1758370979 cites W2091592199 @default.
- W1758370979 cites W2101508556 @default.
- W1758370979 cites W2104663098 @default.
- W1758370979 cites W2107054031 @default.
- W1758370979 cites W2133168427 @default.
- W1758370979 cites W2134100055 @default.
- W1758370979 cites W2138977093 @default.
- W1758370979 cites W2141471647 @default.
- W1758370979 cites W2145554763 @default.
- W1758370979 cites W2148961105 @default.
- W1758370979 cites W2158347994 @default.
- W1758370979 cites W2161114882 @default.
- W1758370979 cites W2170053577 @default.
- W1758370979 cites W2171290692 @default.
- W1758370979 cites W2171705653 @default.
- W1758370979 cites W4322701716 @default.
- W1758370979 doi "https://doi.org/10.1002/hep.26945" @default.
- W1758370979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24806753" @default.
- W1758370979 hasPublicationYear "2014" @default.
- W1758370979 type Work @default.
- W1758370979 sameAs 1758370979 @default.
- W1758370979 citedByCount "90" @default.
- W1758370979 countsByYear W17583709792014 @default.
- W1758370979 countsByYear W17583709792015 @default.
- W1758370979 countsByYear W17583709792016 @default.
- W1758370979 countsByYear W17583709792017 @default.
- W1758370979 countsByYear W17583709792018 @default.
- W1758370979 countsByYear W17583709792019 @default.
- W1758370979 countsByYear W17583709792020 @default.
- W1758370979 countsByYear W17583709792021 @default.
- W1758370979 countsByYear W17583709792022 @default.
- W1758370979 countsByYear W17583709792023 @default.
- W1758370979 crossrefType "journal-article" @default.
- W1758370979 hasAuthorship W1758370979A5004877322 @default.
- W1758370979 hasAuthorship W1758370979A5005096673 @default.
- W1758370979 hasAuthorship W1758370979A5005296486 @default.
- W1758370979 hasAuthorship W1758370979A5010558103 @default.
- W1758370979 hasAuthorship W1758370979A5012677271 @default.
- W1758370979 hasAuthorship W1758370979A5016423407 @default.
- W1758370979 hasAuthorship W1758370979A5017273285 @default.
- W1758370979 hasAuthorship W1758370979A5020693684 @default.
- W1758370979 hasAuthorship W1758370979A5021636467 @default.
- W1758370979 hasAuthorship W1758370979A5034012227 @default.
- W1758370979 hasAuthorship W1758370979A5038734047 @default.
- W1758370979 hasAuthorship W1758370979A5047237529 @default.
- W1758370979 hasAuthorship W1758370979A5051605432 @default.
- W1758370979 hasAuthorship W1758370979A5052925180 @default.
- W1758370979 hasAuthorship W1758370979A5070911765 @default.
- W1758370979 hasAuthorship W1758370979A5078335465 @default.
- W1758370979 hasAuthorship W1758370979A5089069771 @default.
- W1758370979 hasAuthorship W1758370979A5090499433 @default.
- W1758370979 hasAuthorship W1758370979A5090935475 @default.
- W1758370979 hasBestOaLocation W17583709791 @default.
- W1758370979 hasConcept C112446052 @default.
- W1758370979 hasConcept C126322002 @default.
- W1758370979 hasConcept C134018914 @default.
- W1758370979 hasConcept C141359234 @default.