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• W175857542 abstract "Saccharomyces cerevisiaeis so far the only organism where a knock-out mutant in the gene encoding GTP cyclohydrolase I (FOL2) has been obtained. GTP cyclohydrolase I controls thede novobiosynthetic pathway of tetrahydrobiopterin and folic acid. Since deletion of yeastFOL2leads to a recessive auxotrophy for folinic acid, we used a yeastfol2Δmutant for anin vivofunctional assay of heterologous GTP cyclohydrolases I. We show that the GTP cyclohydrolase I, encoded either by theE. coli folEgene or by the human cDNA, complements the yeastfol2Δmutation by restoring folate prototrophy. Furthermore thefolE-3xallele of theE. coligene, carrying three base substitutions, failed to complement the yeastfol2Δdefect. This allele behaved as a negative semidominant to the wild typefolEand, when overexpressed, completely abolished complementation offol2ΔbyfolE.Thus, the yeastfol2null mutant is a suitable system to characterize mutations in genes encoding GTP cyclohydrolase I." @default.
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• W175857542 date "1999-02-01" @default.
• W175857542 modified "2023-09-29" @default.
• W175857542 title "Complementation of thefol2Deletion inSaccharomyces cerevisiaeby Human andEscherichia coliGenes Encoding GTP Cyclohydrolase I" @default.
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• W175857542 doi "https://doi.org/10.1006/bbrc.1998.9951" @default.
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