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• W175859237 abstract "Seizures represent stereotypic electroencephalographic (EEG) and behavioral paroxysms as a consequence of electrical neurological derangement. Seizures are usually described as focal or generalized motor convulsions. Other, nonconvulsive seizure types are common as well and require vigilant patient evaluation for optimal detection. Owing to the admission diagnoses and physiological derangements common to critically ill patients, the intensive care unit (ICU) hosts conditions appropriate for the manifestation of the entire spectrum of seizure disorders. Common etiologies of seizures in the ICU entail primary neurological pathology or secondary to critical illness and clinical management. Alterations in neurotransmitter sensitivity via up- or down regulation of receptors, a decrease in inhibition, or alterations in membrane pump functions may contribute to the high incidence of seizures in an ICU. Particularly prevalent as precipitants of seizures are hypoxia/ischemia, mass lesions, drug toxicity, and metabolic abnormalities. For optimal treatment, early diagnosis of the seizure type and its cause is important to ensure appropriate therapy. Most seizures and their recurrence are easily treated, and attention is focused on ascertaining the cause and correcting any medical abnormality. Convulsive status epilepticus, which represents the most feared seizure state, requires emergent treatment to prevent irreversible brain injury and severe metabolic disturbances. Treatment of seizures with anticonvulsants in an ICU is not without risks, and appropriate judgment and selection of therapeutic drugs are important." @default.
• W175859237 created "2016-06-24" @default.
• W175859237 creator A5079914106 @default.
• W175859237 date "2005-01-01" @default.
• W175859237 modified "2023-10-11" @default.
• W175859237 title "Presentation and Pathophysiology of Seizures in the Critical Care Environment" @default.
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• W175859237 doi "https://doi.org/10.1007/978-1-59259-841-0_1" @default.
• W175859237 hasPublicationYear "2005" @default.
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