Matches in SemOpenAlex for { <https://semopenalex.org/work/W175860483> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W175860483 abstract "The role of the complement system in the pathogenesis of crystal-induced pulmonary inflammation and fibrosis was evaluated using a mouse model of silicosis and congenitally complement-deficient mice. Mice lacking the fifth component of complement (B10.D2/o) were compared to C5-sufficient animals (B10.D2/n) for pulmonary changes following intratracheal instillation of silica crystals. Complement-deficient mice demonstrated a significant reduction compared to complement-sufficient mice in both cell number and protein content of lung lavage fluid throughout the 12 weeks following silica exposure. Lung hydroxyproline content (indicative of collagen deposition) was equivalent for both strains and significantly higher than controls at all times points following silica instillation. Moreover, studies in vitro have shown that silica crystals are capable of activating complement via the alternative pathway. These studies indicate that the complement system may be responsible for some of the pulmonary inflammation, but not fibrosis elicited by silica exposure." @default.
- W175860483 created "2016-06-24" @default.
- W175860483 creator A5062289946 @default.
- W175860483 creator A5078388292 @default.
- W175860483 creator A5085128245 @default.
- W175860483 creator A5090207258 @default.
- W175860483 date "1986-08-01" @default.
- W175860483 modified "2023-09-27" @default.
- W175860483 title "Role of complement in experiment silicosis" @default.
- W175860483 hasPublicationYear "1986" @default.
- W175860483 type Work @default.
- W175860483 sameAs 175860483 @default.
- W175860483 citedByCount "0" @default.
- W175860483 crossrefType "journal-article" @default.
- W175860483 hasAuthorship W175860483A5062289946 @default.
- W175860483 hasAuthorship W175860483A5078388292 @default.
- W175860483 hasAuthorship W175860483A5085128245 @default.
- W175860483 hasAuthorship W175860483A5090207258 @default.
- W175860483 hasConcept C104317684 @default.
- W175860483 hasConcept C111684460 @default.
- W175860483 hasConcept C112313634 @default.
- W175860483 hasConcept C126322002 @default.
- W175860483 hasConcept C127716648 @default.
- W175860483 hasConcept C142724271 @default.
- W175860483 hasConcept C159654299 @default.
- W175860483 hasConcept C185592680 @default.
- W175860483 hasConcept C188082640 @default.
- W175860483 hasConcept C203014093 @default.
- W175860483 hasConcept C2776914184 @default.
- W175860483 hasConcept C2777714996 @default.
- W175860483 hasConcept C2777811718 @default.
- W175860483 hasConcept C2779797417 @default.
- W175860483 hasConcept C2780559512 @default.
- W175860483 hasConcept C2780942790 @default.
- W175860483 hasConcept C2781244666 @default.
- W175860483 hasConcept C55493867 @default.
- W175860483 hasConcept C71924100 @default.
- W175860483 hasConceptScore W175860483C104317684 @default.
- W175860483 hasConceptScore W175860483C111684460 @default.
- W175860483 hasConceptScore W175860483C112313634 @default.
- W175860483 hasConceptScore W175860483C126322002 @default.
- W175860483 hasConceptScore W175860483C127716648 @default.
- W175860483 hasConceptScore W175860483C142724271 @default.
- W175860483 hasConceptScore W175860483C159654299 @default.
- W175860483 hasConceptScore W175860483C185592680 @default.
- W175860483 hasConceptScore W175860483C188082640 @default.
- W175860483 hasConceptScore W175860483C203014093 @default.
- W175860483 hasConceptScore W175860483C2776914184 @default.
- W175860483 hasConceptScore W175860483C2777714996 @default.
- W175860483 hasConceptScore W175860483C2777811718 @default.
- W175860483 hasConceptScore W175860483C2779797417 @default.
- W175860483 hasConceptScore W175860483C2780559512 @default.
- W175860483 hasConceptScore W175860483C2780942790 @default.
- W175860483 hasConceptScore W175860483C2781244666 @default.
- W175860483 hasConceptScore W175860483C55493867 @default.
- W175860483 hasConceptScore W175860483C71924100 @default.
- W175860483 hasLocation W1758604831 @default.
- W175860483 hasOpenAccess W175860483 @default.
- W175860483 hasPrimaryLocation W1758604831 @default.
- W175860483 hasRelatedWork W2088829977 @default.
- W175860483 hasRelatedWork W2150539507 @default.
- W175860483 isParatext "false" @default.
- W175860483 isRetracted "false" @default.
- W175860483 magId "175860483" @default.
- W175860483 workType "article" @default.