FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1758672210> ?p ?o ?g. }

• W1758672210 abstract "Background Historically, oestrogen and progesterone were each commonly used to save threatened pregnancies. In the 1940s it was postulated that their combined use would be synergistic and thereby led to the rationale of combined therapy for women who risked miscarriage. Objectives To determine the efficacy and safety of combined oestrogen and progesterone therapy to prevent miscarriage. Search methods We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (23 June 2013) CENTRAL (OVID) (The Cochrane Library 2013, Issue 6 of 12), MEDLINE (OVID) (1946 to June Week 2 2013), OLDMEDLINE (1946 to 1965), Embase (1974 to Week 25 2013), Embase Classic (1947 to 1973), CINAHL (1994 to 23 June 2013) and reference lists of retrieved studies. Selection criteria We included randomised controlled trials that assessed the effectiveness of combined oestrogen and progesterone for preventing miscarriage. We included one stratified randomised trial and one quasi‐randomised trials. Cluster‐randomised trials were eligible for inclusion but none were identified. We excluded studies published only as abstracts. We included studies that compared oestrogen and progesterone versus placebo or no intervention. Data collection and analysis Two review authors independently assessed trials for inclusion and assessed trial quality. Two review authors extracted data. Data were checked for accuracy. Main results Two trials (281 pregnancies and 282 fetuses) met our inclusion criteria. However, the two trials had significant clinical and methodological heterogeneity such that a meta‐analysis combining trial data was considered inappropriate. One trial (involving 161 pregnancies) was based on women with a history of diabetes. It showed no statistically significant difference between using combined oestrogen and progestogen and using placebo for all our proposed primary outcomes, namely, miscarriage (risk ratio (RR) 0.95, 95% confidence interval (CI) 0.32 to 2.80), perinatal death (RR 0.94, 95% CI 0.53 to 1.69) and preterm birth (less than 34 weeks of gestation) (RR 0.91, 95% CI 0.80 to 1.04). In terms of this review's secondary outcomes, use of combined oestrogen and progestogen was associated with an increased risk of maternal cancer in the reproductive system (RR 6.65, 95% CI 1.56 to 28.29). However, for the outcome of cancer other than that of the reproductive system in mothers, there was no difference between groups. Similarly, there were no differences between the combined oestrogen and progestogen group versus placebo for other secondary outcomes reported: low birthweight of less than 2500 g, genital abnormalities in the offspring, abnormalities other than genital tract in the offspring, cancer in the reproductive system in the offspring, or cancer other than of the reproductive system in the offspring. The second study was based on pregnant women who had undergone in‐vitro fertilisation (IVF). This study showed no difference in the rate of miscarriage between the combined oestrogen and progesterone group and the no treatment group (RR 0.66, 95% CI 0.23 to 1.85). The study did not report on this review's other primary outcomes (perinatal death or rates of preterm birth), nor on any of our proposed secondary outcomes. Authors' conclusions There is an insufficient evidence from randomised controlled trials to assess the use of combined oestrogen and progesterone for preventing miscarriages. We strongly recommend further research in this area." @default.
• W1758672210 created "2016-06-24" @default.
• W1758672210 creator A5015550913 @default.
• W1758672210 creator A5049056912 @default.
• W1758672210 creator A5054684662 @default.
• W1758672210 creator A5060761769 @default.
• W1758672210 date "2013-09-25" @default.
• W1758672210 modified "2023-09-27" @default.
• W1758672210 title "Combined oestrogen and progesterone for preventing miscarriage" @default.
• W1758672210 cites W1481646084 @default.
• W1758672210 cites W1505001959 @default.
• W1758672210 cites W1554034936 @default.
• W1758672210 cites W1587749054 @default.
• W1758672210 cites W1758672210 @default.
• W1758672210 cites W1915983039 @default.
• W1758672210 cites W1973630719 @default.
• W1758672210 cites W1977711494 @default.
• W1758672210 cites W1978173325 @default.
• W1758672210 cites W1982376705 @default.
• W1758672210 cites W1984615597 @default.
• W1758672210 cites W1987524953 @default.
• W1758672210 cites W1998796780 @default.
• W1758672210 cites W1999830611 @default.
• W1758672210 cites W2001924528 @default.
• W1758672210 cites W2005632323 @default.
• W1758672210 cites W2010274639 @default.
• W1758672210 cites W2010444256 @default.
• W1758672210 cites W2011807431 @default.
• W1758672210 cites W2015787557 @default.
• W1758672210 cites W2016096381 @default.
• W1758672210 cites W2028962509 @default.
• W1758672210 cites W2043019860 @default.
• W1758672210 cites W2044427357 @default.
• W1758672210 cites W2049068012 @default.
• W1758672210 cites W2049871125 @default.
• W1758672210 cites W2070108578 @default.
• W1758672210 cites W2075867004 @default.
• W1758672210 cites W2077867999 @default.
• W1758672210 cites W2079263403 @default.
• W1758672210 cites W2079517887 @default.
• W1758672210 cites W2080192023 @default.
• W1758672210 cites W2082408767 @default.
• W1758672210 cites W2086978860 @default.
• W1758672210 cites W2101831564 @default.
• W1758672210 cites W2101843434 @default.
• W1758672210 cites W2119795795 @default.
• W1758672210 cites W2122664063 @default.
• W1758672210 cites W2123272339 @default.
• W1758672210 cites W2130717317 @default.
• W1758672210 cites W2139766621 @default.
• W1758672210 cites W2147024683 @default.
• W1758672210 cites W2151042286 @default.
• W1758672210 cites W2151983841 @default.
• W1758672210 cites W2166156557 @default.
• W1758672210 cites W2169266667 @default.
• W1758672210 cites W2252934623 @default.
• W1758672210 cites W2265167920 @default.
• W1758672210 cites W2294823857 @default.
• W1758672210 cites W2306068341 @default.
• W1758672210 cites W2310496901 @default.
• W1758672210 cites W2322561651 @default.
• W1758672210 cites W2334831808 @default.
• W1758672210 cites W2340600873 @default.
• W1758672210 cites W2395986862 @default.
• W1758672210 cites W2410095571 @default.
• W1758672210 cites W2410744078 @default.
• W1758672210 cites W2412502374 @default.
• W1758672210 cites W2413583060 @default.
• W1758672210 cites W2414091854 @default.
• W1758672210 cites W2417278050 @default.
• W1758672210 cites W2444420462 @default.
• W1758672210 cites W2472074157 @default.
• W1758672210 cites W2588975138 @default.
• W1758672210 cites W2890156120 @default.
• W1758672210 cites W2902914441 @default.
• W1758672210 cites W4232339183 @default.
• W1758672210 cites W4232585152 @default.
• W1758672210 cites W4236708764 @default.
• W1758672210 cites W4251288009 @default.
• W1758672210 cites W87124305 @default.
• W1758672210 doi "https://doi.org/10.1002/14651858.cd009278.pub2" @default.
• W1758672210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7389506" @default.
• W1758672210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24068368" @default.
• W1758672210 hasPublicationYear "2013" @default.
• W1758672210 type Work @default.
• W1758672210 sameAs 1758672210 @default.
• W1758672210 citedByCount "9" @default.
• W1758672210 countsByYear W17586722102013 @default.
• W1758672210 countsByYear W17586722102016 @default.
• W1758672210 countsByYear W17586722102017 @default.
• W1758672210 countsByYear W17586722102020 @default.
• W1758672210 countsByYear W17586722102021 @default.
• W1758672210 countsByYear W17586722102022 @default.
• W1758672210 countsByYear W17586722102023 @default.
• W1758672210 crossrefType "journal-article" @default.
• W1758672210 hasAuthorship W1758672210A5015550913 @default.
• W1758672210 hasAuthorship W1758672210A5049056912 @default.
• W1758672210 hasAuthorship W1758672210A5054684662 @default.
• W1758672210 hasAuthorship W1758672210A5060761769 @default.
• W1758672210 hasBestOaLocation W17586722101 @default.

• next