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- W1759378766 endingPage "210" @default.
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- W1759378766 abstract "This chapter presents an integrated account of a genetic approach to the identification of tumor rejection antigens that has been pursued mainly in the laboratory. These results are presented in the context of the present understanding of antigen recognition by T lymphocytes. Considerable progress has been achieved recently in our understanding of antigen recognition by T lymphocytes. The major histocompatibility complex and the structures of its major protein products are known with a remarkable degree of precision both for mouse and for humans. Several viral antigens that induce tumor rejection have been identified with a great degree of precision because purified viral proteins and genomes are readily obtained. Biochemical fractionations of the tumor cell extracts in order to obtain purified tumor rejection antigens have been attempted. The fractions were tested for their ability to immunize mice so as to make them resistant to tumor challenge. The chapter focuses on the possibility of using a direct genetic approach to identify tumor rejection antigens encoded by the cellular genome. It describes the analysis of the genes coding for these antigens and its implications for T cellmediated immune surveillance, and a similar analysis of a gene coding for a tumor rejection antigen has been described." @default.
- W1759378766 created "2016-06-24" @default.
- W1759378766 creator A5089784419 @default.
- W1759378766 date "1992-01-01" @default.
- W1759378766 modified "2023-09-23" @default.
- W1759378766 title "Toward a Genetic Analysis of Tumor Rejection Antigens" @default.
- W1759378766 cites W1436001149 @default.
- W1759378766 cites W1495900966 @default.
- W1759378766 cites W1497031545 @default.
- W1759378766 cites W1570009082 @default.
- W1759378766 cites W1605072294 @default.
- W1759378766 cites W1650026319 @default.
- W1759378766 cites W1788754252 @default.
- W1759378766 cites W1801100585 @default.
- W1759378766 cites W1871831132 @default.
- W1759378766 cites W1890985457 @default.
- W1759378766 cites W1908875495 @default.
- W1759378766 cites W1947526212 @default.
- W1759378766 cites W1965372133 @default.
- W1759378766 cites W1970930845 @default.
- W1759378766 cites W1972786673 @default.
- W1759378766 cites W1973635674 @default.
- W1759378766 cites W1976119750 @default.
- W1759378766 cites W1977252286 @default.
- W1759378766 cites W1977305815 @default.
- W1759378766 cites W1978781934 @default.
- W1759378766 cites W1980763396 @default.
- W1759378766 cites W1982733393 @default.
- W1759378766 cites W1985774274 @default.
- W1759378766 cites W1986267292 @default.
- W1759378766 cites W1988178079 @default.
- W1759378766 cites W1989360502 @default.
- W1759378766 cites W1990668606 @default.
- W1759378766 cites W1995298928 @default.
- W1759378766 cites W1995317534 @default.
- W1759378766 cites W1999436383 @default.
- W1759378766 cites W2004443127 @default.
- W1759378766 cites W2005139556 @default.
- W1759378766 cites W2006629564 @default.
- W1759378766 cites W2008564146 @default.
- W1759378766 cites W2009209888 @default.
- W1759378766 cites W2011120959 @default.
- W1759378766 cites W2017021901 @default.
- W1759378766 cites W2018685486 @default.
- W1759378766 cites W2019505133 @default.
- W1759378766 cites W2022485234 @default.
- W1759378766 cites W2022861083 @default.
- W1759378766 cites W2023236623 @default.
- W1759378766 cites W2029993034 @default.
- W1759378766 cites W2030391080 @default.
- W1759378766 cites W2035470798 @default.
- W1759378766 cites W2036942515 @default.
- W1759378766 cites W2037218639 @default.
- W1759378766 cites W2038687757 @default.
- W1759378766 cites W2044063726 @default.
- W1759378766 cites W2046760991 @default.
- W1759378766 cites W2047716932 @default.
- W1759378766 cites W2048310562 @default.
- W1759378766 cites W2050830470 @default.
- W1759378766 cites W2054750039 @default.
- W1759378766 cites W2054851015 @default.
- W1759378766 cites W2055510711 @default.
- W1759378766 cites W2059400989 @default.
- W1759378766 cites W2061295749 @default.
- W1759378766 cites W2062774724 @default.
- W1759378766 cites W2073795899 @default.
- W1759378766 cites W2075608929 @default.
- W1759378766 cites W2076393247 @default.
- W1759378766 cites W2076726803 @default.
- W1759378766 cites W2078352345 @default.
- W1759378766 cites W2080757497 @default.
- W1759378766 cites W2082108597 @default.
- W1759378766 cites W2082173837 @default.
- W1759378766 cites W2083424266 @default.
- W1759378766 cites W2085975031 @default.
- W1759378766 cites W2087360336 @default.
- W1759378766 cites W2094371923 @default.
- W1759378766 cites W2096273252 @default.
- W1759378766 cites W2100427081 @default.
- W1759378766 cites W2105816724 @default.
- W1759378766 cites W2106801710 @default.
- W1759378766 cites W2108366190 @default.
- W1759378766 cites W2110338639 @default.
- W1759378766 cites W2111970653 @default.
- W1759378766 cites W2112378746 @default.
- W1759378766 cites W2123589562 @default.
- W1759378766 cites W2125170171 @default.
- W1759378766 cites W2128983326 @default.
- W1759378766 cites W2129980482 @default.
- W1759378766 cites W2130651544 @default.
- W1759378766 cites W2131965013 @default.
- W1759378766 cites W2135760279 @default.
- W1759378766 cites W2142647027 @default.
- W1759378766 cites W2150650084 @default.
- W1759378766 cites W2153918116 @default.
- W1759378766 cites W2159466351 @default.
- W1759378766 cites W2159609881 @default.
- W1759378766 cites W2170889183 @default.