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- W1759488108 abstract "Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested the hypothesis that DMN dysfunction contributes to VH in PD.Resting state functional data was acquired from individuals with PD with VH (PDVH) and without VH (PDnonVH), matched for levodopa drug equivalent dose, and a healthy control group (HC). Independent component analysis was used to investigate group differences in functional connectivity within the DMN. In addition, we investigated whether the functional changes associated with hallucinations were accompanied by differences in cortical thickness.There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC. Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group.Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher connectivity is associated with VH. We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to positive symptom generation in PD." @default.
- W1759488108 created "2016-06-24" @default.
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- W1759488108 date "2014-07-01" @default.
- W1759488108 modified "2023-10-14" @default.
- W1759488108 title "The default mode network is disrupted in parkinson's disease with visual hallucinations" @default.
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- W1759488108 doi "https://doi.org/10.1002/hbm.22577" @default.
- W1759488108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4657500" @default.
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