Matches in SemOpenAlex for { <https://semopenalex.org/work/W175998601> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W175998601 endingPage "464" @default.
- W175998601 startingPage "459" @default.
- W175998601 abstract "Objective: To assess the effects of recombinant human DNase (rhDNase) therapy on the cost of treating respiratory tract infections (RTIs) in patients with cystic fibrosis. Design: We prospectively documented the use of healthcare services among 968 patients with cystic fibrosis who participated in a recent Phase III double-blind, multicenter, clinical trial in which patients were assigned randomly to receive either rhDNase 2.5 mg once daily, rhDNase 2.5 mg twice daily, or placebo. All patients were followed for 24 weeks. Data from secondary sources were used to estimate a total cost of RTI-related care (excluding the cost of study therapy) for each trial participant, based on observed levels of resource use. Main Outcome Measures: Number of RTI-related hospital admissions, days of RTI-related outpatient antibiotic therapy (intravenous and oral), and total costs of RTI-related care (excluding the cost of study therapy). Results: Patients randomized to receive rhDNase once daily averaged 0.15 fewer RTI-related hospital admissions (0.41 vs 0.56 for placebo; p < 0.05) and 1.5 fewer days of RTI-related outpatient intravenous antibiotic therapy (2.9 vs 4.4; p < 0.05). Patients randomized to receive rhDNase twice daily had 0.14 fewer hospital admissions (p < 0.01), but no reduction in outpatient intravenous antibiotic therapy. Compared with placebo, the cost of treating RTIs over 24 weeks was $814–1682 less among patients receiving rhDNase. Conclusions: rhDNase therapy reduced the costs of treating RTIs in patients with cystic fibrosis; assuming once-daily dosing, these savings would offset about one-third of the cost of such therapy." @default.
- W175998601 created "2016-06-24" @default.
- W175998601 creator A5017334876 @default.
- W175998601 creator A5021788583 @default.
- W175998601 creator A5055762239 @default.
- W175998601 creator A5060508096 @default.
- W175998601 creator A5081740012 @default.
- W175998601 date "1995-05-01" @default.
- W175998601 modified "2023-09-27" @default.
- W175998601 title "Effects of Recombinant Human DNase Therapy on Healthcare use and Costs in Patients with Cystic Fibrosis" @default.
- W175998601 cites W1969194020 @default.
- W175998601 cites W1973665755 @default.
- W175998601 cites W1997182007 @default.
- W175998601 cites W2014910738 @default.
- W175998601 cites W2023546954 @default.
- W175998601 cites W2061909665 @default.
- W175998601 cites W2085491594 @default.
- W175998601 cites W2092036984 @default.
- W175998601 cites W2150399236 @default.
- W175998601 cites W2333398204 @default.
- W175998601 doi "https://doi.org/10.1177/106002809502900501" @default.
- W175998601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7655127" @default.
- W175998601 hasPublicationYear "1995" @default.
- W175998601 type Work @default.
- W175998601 sameAs 175998601 @default.
- W175998601 citedByCount "40" @default.
- W175998601 countsByYear W1759986012013 @default.
- W175998601 countsByYear W1759986012015 @default.
- W175998601 countsByYear W1759986012016 @default.
- W175998601 countsByYear W1759986012018 @default.
- W175998601 countsByYear W1759986012021 @default.
- W175998601 crossrefType "journal-article" @default.
- W175998601 hasAuthorship W175998601A5017334876 @default.
- W175998601 hasAuthorship W175998601A5021788583 @default.
- W175998601 hasAuthorship W175998601A5055762239 @default.
- W175998601 hasAuthorship W175998601A5060508096 @default.
- W175998601 hasAuthorship W175998601A5081740012 @default.
- W175998601 hasConcept C126322002 @default.
- W175998601 hasConcept C142724271 @default.
- W175998601 hasConcept C168563851 @default.
- W175998601 hasConcept C1862650 @default.
- W175998601 hasConcept C204787440 @default.
- W175998601 hasConcept C27081682 @default.
- W175998601 hasConcept C2776012195 @default.
- W175998601 hasConcept C2776938444 @default.
- W175998601 hasConcept C2777288759 @default.
- W175998601 hasConcept C534529494 @default.
- W175998601 hasConcept C535046627 @default.
- W175998601 hasConcept C71924100 @default.
- W175998601 hasConceptScore W175998601C126322002 @default.
- W175998601 hasConceptScore W175998601C142724271 @default.
- W175998601 hasConceptScore W175998601C168563851 @default.
- W175998601 hasConceptScore W175998601C1862650 @default.
- W175998601 hasConceptScore W175998601C204787440 @default.
- W175998601 hasConceptScore W175998601C27081682 @default.
- W175998601 hasConceptScore W175998601C2776012195 @default.
- W175998601 hasConceptScore W175998601C2776938444 @default.
- W175998601 hasConceptScore W175998601C2777288759 @default.
- W175998601 hasConceptScore W175998601C534529494 @default.
- W175998601 hasConceptScore W175998601C535046627 @default.
- W175998601 hasConceptScore W175998601C71924100 @default.
- W175998601 hasIssue "5" @default.
- W175998601 hasLocation W1759986011 @default.
- W175998601 hasLocation W1759986012 @default.
- W175998601 hasOpenAccess W175998601 @default.
- W175998601 hasPrimaryLocation W1759986011 @default.
- W175998601 hasRelatedWork W1993177358 @default.
- W175998601 hasRelatedWork W2017550532 @default.
- W175998601 hasRelatedWork W2026198808 @default.
- W175998601 hasRelatedWork W2167581782 @default.
- W175998601 hasRelatedWork W2418502454 @default.
- W175998601 hasRelatedWork W2947032946 @default.
- W175998601 hasRelatedWork W3034070945 @default.
- W175998601 hasRelatedWork W3159250744 @default.
- W175998601 hasRelatedWork W4233016836 @default.
- W175998601 hasRelatedWork W4256514411 @default.
- W175998601 hasVolume "29" @default.
- W175998601 isParatext "false" @default.
- W175998601 isRetracted "false" @default.
- W175998601 magId "175998601" @default.
- W175998601 workType "article" @default.