Matches in SemOpenAlex for { <https://semopenalex.org/work/W1760275003> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1760275003 endingPage "26" @default.
- W1760275003 startingPage "26" @default.
- W1760275003 abstract "26 Objectives The potent serotonin (5HT) releaser MDMA (3,4-methylenedioxy-N-methamphetamine, “ecstasy”) causes 5HT depletion with neurotoxic loss of serotonin transporters (SERT) and upregulation of 5HT2A receptors in animal models. Some, but not all, imaging studies in human ecstasy users have observed decreased SERT binding. In vivo evidence for MDMA-induced changes in postsynaptic 5HT2A receptors in humans has been scarce. This is the first study investigating both components of the 5HT system in the same group of users. Methods Positron emission tomography (PET) using the specific SERT ligand [11C]DASB and the selective 5HT2A receptor ligand [11C]MDL 100907 was performed in 13 detoxified and chronic moderate ecstasy users (XTC) and 13 drug naive healthy controls (HC). Regional SERT availability and 5HT2A receptor availability were analyzed using a two-tissue compartment model (2TCM) with arterial input function. Relationships between parameters of ecstasy use and BPND were analyzed using Pearson correlation coefficients. Results Compared to HC, XTC displayed significantly increased 5HT2A receptors availability in cortical regions (DLPFC and parietal cortex, p Conclusions Our results support that chronic moderate ecstasy use in humans might lead to neurotoxic damage to 5HT nerve terminals in the cortex, and that this neurotoxicity might be associated with compensatory upregulation of postsynaptic 5HT2A receptors. This study adds to the growing body of evidence suggesting the potential detrimental effects of this widely used recreational drug on the 5HT system. Reversibility of these changes upon sustained abstinence remains to be fully documented. Research Support Funded by NIDA" @default.
- W1760275003 created "2016-06-24" @default.
- W1760275003 creator A5048913785 @default.
- W1760275003 creator A5054945342 @default.
- W1760275003 creator A5058205666 @default.
- W1760275003 creator A5071319145 @default.
- W1760275003 creator A5072395467 @default.
- W1760275003 creator A5074474145 @default.
- W1760275003 creator A5083715547 @default.
- W1760275003 creator A5087635866 @default.
- W1760275003 creator A5090929004 @default.
- W1760275003 date "2011-05-01" @default.
- W1760275003 modified "2023-09-28" @default.
- W1760275003 title "The 5-HT2A receptor and serotonin transporter in ecstasy users evaluated with [11C]MDL 100907 and [11C]DASB" @default.
- W1760275003 hasPublicationYear "2011" @default.
- W1760275003 type Work @default.
- W1760275003 sameAs 1760275003 @default.
- W1760275003 citedByCount "0" @default.
- W1760275003 crossrefType "journal-article" @default.
- W1760275003 hasAuthorship W1760275003A5048913785 @default.
- W1760275003 hasAuthorship W1760275003A5054945342 @default.
- W1760275003 hasAuthorship W1760275003A5058205666 @default.
- W1760275003 hasAuthorship W1760275003A5071319145 @default.
- W1760275003 hasAuthorship W1760275003A5072395467 @default.
- W1760275003 hasAuthorship W1760275003A5074474145 @default.
- W1760275003 hasAuthorship W1760275003A5083715547 @default.
- W1760275003 hasAuthorship W1760275003A5087635866 @default.
- W1760275003 hasAuthorship W1760275003A5090929004 @default.
- W1760275003 hasConcept C118552586 @default.
- W1760275003 hasConcept C126322002 @default.
- W1760275003 hasConcept C126855140 @default.
- W1760275003 hasConcept C15744967 @default.
- W1760275003 hasConcept C169760540 @default.
- W1760275003 hasConcept C170493617 @default.
- W1760275003 hasConcept C197341189 @default.
- W1760275003 hasConcept C2775842073 @default.
- W1760275003 hasConcept C2775864247 @default.
- W1760275003 hasConcept C2778897192 @default.
- W1760275003 hasConcept C2779488553 @default.
- W1760275003 hasConcept C2779491297 @default.
- W1760275003 hasConcept C2908747647 @default.
- W1760275003 hasConcept C29730261 @default.
- W1760275003 hasConcept C53910766 @default.
- W1760275003 hasConcept C60592354 @default.
- W1760275003 hasConcept C71924100 @default.
- W1760275003 hasConcept C98274493 @default.
- W1760275003 hasConceptScore W1760275003C118552586 @default.
- W1760275003 hasConceptScore W1760275003C126322002 @default.
- W1760275003 hasConceptScore W1760275003C126855140 @default.
- W1760275003 hasConceptScore W1760275003C15744967 @default.
- W1760275003 hasConceptScore W1760275003C169760540 @default.
- W1760275003 hasConceptScore W1760275003C170493617 @default.
- W1760275003 hasConceptScore W1760275003C197341189 @default.
- W1760275003 hasConceptScore W1760275003C2775842073 @default.
- W1760275003 hasConceptScore W1760275003C2775864247 @default.
- W1760275003 hasConceptScore W1760275003C2778897192 @default.
- W1760275003 hasConceptScore W1760275003C2779488553 @default.
- W1760275003 hasConceptScore W1760275003C2779491297 @default.
- W1760275003 hasConceptScore W1760275003C2908747647 @default.
- W1760275003 hasConceptScore W1760275003C29730261 @default.
- W1760275003 hasConceptScore W1760275003C53910766 @default.
- W1760275003 hasConceptScore W1760275003C60592354 @default.
- W1760275003 hasConceptScore W1760275003C71924100 @default.
- W1760275003 hasConceptScore W1760275003C98274493 @default.
- W1760275003 hasLocation W17602750031 @default.
- W1760275003 hasOpenAccess W1760275003 @default.
- W1760275003 hasPrimaryLocation W17602750031 @default.
- W1760275003 hasRelatedWork W1970428433 @default.
- W1760275003 hasRelatedWork W1983907106 @default.
- W1760275003 hasRelatedWork W1986219496 @default.
- W1760275003 hasRelatedWork W1992963529 @default.
- W1760275003 hasRelatedWork W2005704843 @default.
- W1760275003 hasRelatedWork W2037618452 @default.
- W1760275003 hasRelatedWork W2051376367 @default.
- W1760275003 hasRelatedWork W2074523805 @default.
- W1760275003 hasRelatedWork W2092359708 @default.
- W1760275003 hasRelatedWork W2096155592 @default.
- W1760275003 hasRelatedWork W2124498680 @default.
- W1760275003 hasRelatedWork W2130423340 @default.
- W1760275003 hasRelatedWork W2155783963 @default.
- W1760275003 hasRelatedWork W2155890773 @default.
- W1760275003 hasRelatedWork W2156723449 @default.
- W1760275003 hasRelatedWork W2224635535 @default.
- W1760275003 hasRelatedWork W2741398673 @default.
- W1760275003 hasRelatedWork W2784804478 @default.
- W1760275003 hasRelatedWork W2789328564 @default.
- W1760275003 hasRelatedWork W2883903933 @default.
- W1760275003 hasVolume "52" @default.
- W1760275003 isParatext "false" @default.
- W1760275003 isRetracted "false" @default.
- W1760275003 magId "1760275003" @default.
- W1760275003 workType "article" @default.