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- W1760418539 abstract "This chapter explores skin grafts that are used commonly to measure genetic differences among individuals and, of most importance to cellular immunologists, competence of the thymus-dependent immune system. The immunological and medical aspects of skin grafting are reviewed as well as techniques of clinical skin grafting. The chapter describes the techniques of transplanting and evaluating skin grafts in mice and rats, the most widely used experimental animals in cancer research, immunology, and immunogenetics laboratories. The simplest way of skin grafting small rodents, whose skin is so mobile and loosely adherent to the underlying body wall, apparently would be to excise a full-thickness piece of skin and suture or clip into place a graft of comparable size and thickness. The chapter also reviews that this is the least elegant and desirable method because it subjects the graft to ischemic necrosis; revascularization can occur only from the cut edges of the surrounding host skin, and, especially with large grafts, there is massive nonspecific degeneration and sloughing of necrotic tissue, which makes it difficult to assess initial graft “take” and subsequent immunoiogically mediated rejection." @default.
- W1760418539 created "2016-06-24" @default.
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- W1760418539 date "1984-01-01" @default.
- W1760418539 modified "2023-10-10" @default.
- W1760418539 title "[3] Skin grafting" @default.
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- W1760418539 doi "https://doi.org/10.1016/s0076-6879(84)08070-8" @default.
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