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• W1760435364 abstract "Article1 March 1954THE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMAJ. A. HERSCHFUS, M.D., A. SALOMON, M.D., M. S. SEGAL, M.D., F.A.C.P.J. A. HERSCHFUS, M.D.Search for more papers by this author, A. SALOMON, M.D.Search for more papers by this author, M. S. SEGAL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-3-506 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the discovery of a new group of analgesic compounds in 1939,1 one of these, 1-methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride, was intensively investigated. This drug is generally known under the name of Demerol, meperidine, Dolantin, Pethidine or Isonipecaine, and its chemical structure is shown in figure 1.Pharmacologic investigations showed that Demerol has a weak atropine-like and a stronger papaverine-like action on smooth muscle2; these actions were demonstrable on spastic or stimulated smooth muscle. Schaumann1, 3also demonstrated spasmolytic action on intestinal or bronchial smooth muscle whether contraction was caused by a cholinergic drug, by nerve stimulation or by...Bibliography1. EislebSchaumann OO: Dolantin, ein neuartiges Spasmolytikum und Analgetikum, Deutsch. med. Wchnschr. 65: 967, 1939. CrossrefGoogle Scholar2. YonkmanNothHecht FFPHHH: Demerol: a new synthetic analgetic spasmolytic and sedative agent. I. Pharmacologic studies, Ann. Int. Med. 21: 7, 1944. LinkGoogle Scholar3. Schaumann O: Über eine neue Klasse von Verbindungen mit spasmolitischer und zentral analgetischer Wirksamkeit unter besonderer Beruchsichtigung des 1-methyl4-phenyl piperidine-4-carbondureathyl esters (Dolantin), Arch. f. exper. Path. u. Pharmakol. 196: 109, 1940. CrossrefGoogle Scholar4. DuguidHeathcote AMRS: The pharmacological action of ethyl methyl phenylpiperidine carboxylate, Quart. J. Pharm. and Pharmacol. 13: 318, 1940. Google Scholar5. GruberHartGruber CMERCM: The pharmacology and toxicology of the ethyl ester of 1-methyl-4-phenylpiperidine-4-carboxylic acid (Demerol), J. Pharmacol. and Exper. Therap. 73: 319, 1941. Google Scholar6. LoewKaiserMoore ERMEV: Effect of various drugs on experimental asthma produced in guinea pigs by exposure to atomized histamine, J. Pharmacol. and Exper. Therap. 86: 1, 1946. MedlineGoogle Scholar7. CurryFuchsLeard JJJESE: Clinical implications of the effect of various anticholinergic agents in modifying the pulmonary response of asthmatic subjects to injected methacholine, Bull. New England M. Center 10: 164, 1948. MedlineGoogle Scholar8. RobySchumann CWR: Demerol and scopolamine in labor, Am. J. Obst. and Gynec. 45: 318, 1943. CrossrefGoogle Scholar9. GilbertDixon GAB: Observations on Demerol as an obstetric analgetic, Am. J. Obst. and Gynec. 45: 320, 1943. CrossrefGoogle Scholar10. Schumann WR: Demerol and scopolamine in labor, Am. J. Obst. and Gynec. 47: 93, 1944. CrossrefGoogle Scholar11. JamesMurphyFowell HDRADM: Major surgery in asthmatic patient, S. Clin. North America 26: 676, 1946. MedlineGoogle Scholar12. YonkmanNothHecht FFPHHH: Demerol: a new synthetic analgetic spasmolytic and sedative agent. II. Clinical observations, Ann. Int. Med. 21: 17, 1944. LinkGoogle Scholar13. Curry JJ: Clinical appraisal of Demerol, Benadryl and Pyribenzamine, M. Clin. North America 30: 1138, 1946. CrossrefMedlineGoogle Scholar14. Barach AL: Physiologic and antibiotic therapy of bronchial asthma, Connecticut M. J. 11: 819, 1947. MedlineGoogle Scholar15. Hepburn J: Pethidine for asthma, Brit. M. J. 1: 174, 1945. Google Scholar16. Hoffman R: Demerol: a new departure in analgesia; an evaluation of present therapeutic claims, Anesth. and Analg. 22: 336, 1943. CrossrefGoogle Scholar17. Powers BR: Observations of the use of Demerol, South. M. J. 40: 870, 1947. CrossrefMedlineGoogle Scholar18. Segal MS: The management of the patient with severe bronchial asthma, 1950, Charles C Thomas Co., Springfield, Ill. Google Scholar19. Spain WC: The medical management of attacks of bronchial asthma, Ann. Allergy 6: 53, 1948. MedlineGoogle Scholar20. Wittich FW: Diagnosis and treatment of common forms of respiratory allergy, Minnesota Med. 32: 702, 1949. MedlineGoogle Scholar21. Rackemann FM: Allergy, a review of the literature of 1944 and 1945, with comments on future problems, Arch. Int. Med. 78: 108, 1948. CrossrefGoogle Scholar22. RoweRowe AHAH: Bronchial asthma in patients over the age of fiftyfive years; diagnosis and treatment, Ann. Allergy 5: 509, 1947. MedlineGoogle Scholar23. RoweRowe AHAH: Bronchial asthma in infants and children; its diagnosis and treatment, California Med. 69: 261, 1948. MedlineGoogle Scholar24. Abramson HA: Therapy of asthma with reference to its psychodynamic pharmacology, Bull. New York Acad. Med. 25: 345, 1949. MedlineGoogle Scholar25. Feinberg SM: New drugs in treatment of allergic diseases, Postgrad. Med. 3: 92, 1948. CrossrefMedlineGoogle Scholar26. UngerGordon LBF: Bronchial asthma (IV); critical review of the literature, Ann. Allergy 6: 159, 1948. MedlineGoogle Scholar27. Guttman SA: Demerol: caution in administration to patients with intracranial lesions, J. A. M. A. 124: 155, 1944. CrossrefGoogle Scholar28. Way EL: Barbiturate antagonism of isonipecaine convulsions and isonipecaine potentiation of barbiturate depression, J. Pharmacol. and Exper. Therap. 87: 265, 1946. MedlineGoogle Scholar29. Andrews HL: Cortical effects of Demerol, J. Pharmacol. and Exper. Therap. 76: 89, 1942. Google Scholar30. LehmanAitken RAT: The determination of Demerol in urine with preliminary observations on its excretion in man, J. Lab. and Clin. Med. 28: 787, 1943. Google Scholar31. WayGimbleLigon ELAIEW: The tissue distribution of isonipecaine (Demerol), Federation Proc. 6: 381, 1947. Google Scholar32. HerschfusRubitskyBeakeyBresnickLevinsonSegal JAHJJFELMS: Evaluation of therapeutic substances employed for the relief of bronchial asthma, Internat. Arch. Allergy 2: 97, 1951. CrossrefGoogle Scholar33. HerschfusBresnickSegal JAEMS: Pulmonary function studies in bronchial asthma. I. In the control state. II. After treatment, Am. J. Med. 14: 23, 34, 1953. CrossrefMedlineGoogle Scholar34. SegalDulfano MSMJ: Chronic pulmonary emphysema. Physiopathology and treatment, 1953, Grune and Stratton, New York. Google Scholar35. SegalDulfanoHerschfusShanks MSMJJAJA: Respiratory acidosis, pathogenesis and treatment, Ann. Allergy 11: 206, 1953. MedlineGoogle Scholar36. DulfanoMackSegal MJFXMS: Treatment of respiratory acidosis with N-allylnormorphine (Nalline), New England J. Med. 248: 931, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 22, 1953.From the Department of Medicine, Tufts College Medical School, and the Department of Inhalational Therapy, Boston City Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGENERAL ANESTHETICS AND ADJUVANTSPATHOGENESIS OF PULMONARY HYPERTENSION; BRONCHIAL ASTHMA AND BRONCHIECTASISThe Asthmatic Narcotic AddictThe Role of Chlorpromazine in the Treatment of Bronchial Asthma and Chronic Pulmonary EmphysemaCare of the Patient With Chronic Pulmonary DiseaseRELAXANTS AND THE HUMAN CARDIO-VASCULAR SYSTEM 1 March 1954Volume 40, Issue 3Page: 506-515KeywordsAnalgesicsAsthmaCholinergicsDrugsHospital medicineNervesSmooth muscles Issue Published: 1 March 1954 PDF downloadLoading ..." @default.
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