Matches in SemOpenAlex for { <https://semopenalex.org/work/W176043734> ?p ?o ?g. }
- W176043734 abstract "Monoclonal antibody (mAb) technology has reached a state of maturity making it possible to rapidly discover and produce fully human mAbs which neutralize any given virus in vitro. Several antibodies have also shown good prophylactic and therapeutic efficacy in relevant animal models of viral disease. Surprisingly, only one antiviral mAb has been licensed to date; it is used to prevent infection with respiratory syncytial virus in at-risk infants. Certain paradigms of mAbs prevailing in industry and academia are obstacles to the development of further antiviral antibodies for clinical use. There is a perception that mAbs are much more effective in prophylactic than therapeutic use, offer limited breadth of protection against different viral strains, are prone to select neutralization escape variants and need to be given in high doses, which are still comparatively costly to manufacture. Based on a review of the literature and our own data, we propose that by combining two or more non- competing neutralizing antibodies, viral escape can effectively be controlled and in case of synergistic action of the mAbs it may be possible to significantly reduce the total antibody concentration required for protection. The combination of mAbs with specific antiviral drugs has the potential to expand their use from pre- and post-exposure prophylaxis to therapy of acute and chronic viral infections." @default.
- W176043734 created "2016-06-24" @default.
- W176043734 creator A5026555786 @default.
- W176043734 creator A5066575559 @default.
- W176043734 date "2006-01-01" @default.
- W176043734 modified "2023-09-26" @default.
- W176043734 title "Human monoclonal antibodies for prophylaxis and therapy of viral infections" @default.
- W176043734 cites W123780011 @default.
- W176043734 cites W1488999392 @default.
- W176043734 cites W1531785323 @default.
- W176043734 cites W1601908524 @default.
- W176043734 cites W1607832269 @default.
- W176043734 cites W1856085589 @default.
- W176043734 cites W1968878148 @default.
- W176043734 cites W1974368619 @default.
- W176043734 cites W1975490802 @default.
- W176043734 cites W1980305117 @default.
- W176043734 cites W1987266564 @default.
- W176043734 cites W1990291720 @default.
- W176043734 cites W1992179441 @default.
- W176043734 cites W1992274022 @default.
- W176043734 cites W1993575340 @default.
- W176043734 cites W1996061504 @default.
- W176043734 cites W1997677784 @default.
- W176043734 cites W1998383538 @default.
- W176043734 cites W2001086204 @default.
- W176043734 cites W2008818075 @default.
- W176043734 cites W2010125163 @default.
- W176043734 cites W2012225701 @default.
- W176043734 cites W2012362118 @default.
- W176043734 cites W2017560695 @default.
- W176043734 cites W2019706667 @default.
- W176043734 cites W2023434411 @default.
- W176043734 cites W2023767102 @default.
- W176043734 cites W2024798162 @default.
- W176043734 cites W2030452894 @default.
- W176043734 cites W2031154947 @default.
- W176043734 cites W2031996240 @default.
- W176043734 cites W2034287217 @default.
- W176043734 cites W2035057272 @default.
- W176043734 cites W2035316919 @default.
- W176043734 cites W2036133029 @default.
- W176043734 cites W2036907186 @default.
- W176043734 cites W2036990412 @default.
- W176043734 cites W2038231925 @default.
- W176043734 cites W2041743555 @default.
- W176043734 cites W2044326018 @default.
- W176043734 cites W2048257343 @default.
- W176043734 cites W2049476960 @default.
- W176043734 cites W2054383673 @default.
- W176043734 cites W2058199315 @default.
- W176043734 cites W2059017948 @default.
- W176043734 cites W2063245379 @default.
- W176043734 cites W2065596070 @default.
- W176043734 cites W2066276445 @default.
- W176043734 cites W2068084279 @default.
- W176043734 cites W2068635250 @default.
- W176043734 cites W2068935062 @default.
- W176043734 cites W2069659715 @default.
- W176043734 cites W2071267501 @default.
- W176043734 cites W2074983991 @default.
- W176043734 cites W2075964526 @default.
- W176043734 cites W2076932222 @default.
- W176043734 cites W2077945404 @default.
- W176043734 cites W2086198097 @default.
- W176043734 cites W2089887554 @default.
- W176043734 cites W2091855294 @default.
- W176043734 cites W2096497391 @default.
- W176043734 cites W2096527227 @default.
- W176043734 cites W2096931909 @default.
- W176043734 cites W2097594050 @default.
- W176043734 cites W2098695079 @default.
- W176043734 cites W2106117552 @default.
- W176043734 cites W2109844644 @default.
- W176043734 cites W2112011162 @default.
- W176043734 cites W2114132885 @default.
- W176043734 cites W2117458024 @default.
- W176043734 cites W2117845861 @default.
- W176043734 cites W2136445320 @default.
- W176043734 cites W2138186489 @default.
- W176043734 cites W2139532931 @default.
- W176043734 cites W2146900701 @default.
- W176043734 cites W2147054984 @default.
- W176043734 cites W2149388982 @default.
- W176043734 cites W2153537922 @default.
- W176043734 cites W2155130452 @default.
- W176043734 cites W2155250251 @default.
- W176043734 cites W2156720884 @default.
- W176043734 cites W2158178504 @default.
- W176043734 cites W2160995968 @default.
- W176043734 cites W2161554697 @default.
- W176043734 cites W2162730915 @default.
- W176043734 cites W2163486922 @default.
- W176043734 cites W2165376644 @default.
- W176043734 cites W2170647043 @default.
- W176043734 cites W2409720954 @default.
- W176043734 cites W95236298 @default.
- W176043734 doi "https://doi.org/10.1007/978-0-387-31047-3_18" @default.
- W176043734 hasPublicationYear "2006" @default.
- W176043734 type Work @default.