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- W1760551495 abstract "Clarify the relationship between lowering intraocular pressure (IOP) action of cholinomimetic drugs and muscarinic receptor subtypes.Measuring rabbit IOP with gas driving ophthalmotonometer, measuring size of pupil with pupil rule and measuring contraction of rabbit iris by iris experiment in vitro. Figuring out pD2 of cholinomimetic drugs and pA2 of the antagonists of muscarinic receptor subtypes.The order of effect on lowering IOP and miosis of cholinomimetic drugs is Erycibele Alkaloid > Aceclidine > Pilocarpine and the order of effect on constracting iris is Erycibele Alkaloid > Pilocarpine > Aceclidine. The sequence of antagonistic effect of subtype antagonists is 4-DAMP(M3) > Pirenzepine(M1) > Gallamine(M2).Effect cholinomimetics on lowing IOP and miosis is primary mediated by M3 receptor, next by M1 receptor and has little relation with M2 receptor." @default.
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- W1760551495 date "2000-12-01" @default.
- W1760551495 modified "2023-09-27" @default.
- W1760551495 title "[The muscarinic receptor subtype study of the action on lowering IOP of cholinomimetic drugs]." @default.
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