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• W1760719812 abstract "textabstractPercutaneous coronary intervention is a major treatment strategy for patients with coronary arterydisease, and currently coronary stents are widely used in the world.1 Although stent implantation itselfhas shown to reduce restenosis by preventing both early elastic recoil and late vascular remodelingcompared to balloon angioplasty, in-stent restenosis (ISR) still occurs in 10-40% of patients and hasbeen the ‘Achilles’ heel’ of coronary interventions, frequently resulting in repeated revascularization.2,3Restenosis after coronary stenting occurs secondary to the accumulation of smooth muscle cells andextracellular matrix proteoglycans.4 Despite the sophistication of the new techniques and enormousadvance in devices, ISR requiring repeat procedure has been considered as a main limitation ofcoronary stenting.The advent of drug eluting stents (DES), which consist of a drug (immunosuppressive or antiproliferativedrug), a polymer and a metallic platform, has revolutionized the practice of interventional cardiology bysignificantly reducing the rates of restenosis and repeat revascularization as compared to bare metalstents.5 After the first approval of DES, a large number of patients with coronary artery disease haveundergone percutaneous revascularization with DES. However, many trials conducted in the ‘real world’showed that the problem of restenosis was not completely resolved and still persists. Effect of DES forpatients at high risk for ISR, such as acute myocardial infarction, small coronary vessels, aorto-ostiallesions, or lesions of chronic total occlusion (Part 1 of this thesis), have not been fully investigated. Inaddition, certain potential safety concerns regarding the widespread use of DES have arisen. The mostnotable drawback of DES is that they could increase the risk of thrombotic complication, especially latestent thrombosis6, although its incidence is low.7 The increased risk of thrombosis with DES utilizationmay be associated with altered endothelial function8 and/or delayed vascular healing9 induced bycytotoxic and cytostatic drug use. Localized hypersensitivity reactions to the polymer coating of DES anddrug itself may also contribute to stent thrombosis.10 To retain the positive clinical aspects of DES andovercome their drawbacks, new concept stents have been developed (Part 2 of this thesis)." @default.
• W1760719812 created "2016-06-24" @default.
• W1760719812 creator A5056345513 @default.
• W1760719812 date "2005-07-01" @default.
• W1760719812 modified "2023-09-26" @default.
• W1760719812 title "Drug Eluting Stent Implantation for High Risk Patients and Novel Technologies in Percutaneous Coronary Intervention" @default.
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