Matches in SemOpenAlex for { <https://semopenalex.org/work/W1760737596> ?p ?o ?g. }
- W1760737596 endingPage "629" @default.
- W1760737596 startingPage "622" @default.
- W1760737596 abstract "Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of Ca2+ ([Ca2+]i) has been supported. MeHg alters [Ca2+]i by at least two mechanisms. First, it disrupts regulation of Ca2+ from an intracellular Ca2+ pool and second, it increases the permeability of the plasma membrane to Ca2+. MeHg also blocks plasma membrane voltage-dependent Ca2+ and Na+ channels in addition to activating a nonspecific transmembrane cation conductance. Chronic MeHg exposure results in ultrastructural changes and accumulation of MeHg within mitochondria. In vitro, MeHg inhibits several mitochondrial enzymes and depolarizes the mitochondria membrane subsequently reducing ATP production and Ca2+ buffering capacity. Inhibition of protein synthesis is observed after in vivo or in vitro exposures of MeHg and may be an early effect of MeHg. Thus, the early cellular effects of exposure to MeHg are diverse and cell damage likely occurs by more than one mechanism, the effects of which may be additive or synergistic.— Atchison, W. D., Hare, M. F. Mechanisms of methylmercury-induced neurotoxicity. FASEB J. 8: 622-629; 1994." @default.
- W1760737596 created "2016-06-24" @default.
- W1760737596 creator A5014156549 @default.
- W1760737596 creator A5034601735 @default.
- W1760737596 date "1994-06-01" @default.
- W1760737596 modified "2023-10-16" @default.
- W1760737596 title "Mechanisms of methylmercury‐induced neurotoxicity" @default.
- W1760737596 cites W1524189815 @default.
- W1760737596 cites W1928804285 @default.
- W1760737596 cites W1929075031 @default.
- W1760737596 cites W1937726001 @default.
- W1760737596 cites W1964428482 @default.
- W1760737596 cites W1964439635 @default.
- W1760737596 cites W1966377830 @default.
- W1760737596 cites W1969065565 @default.
- W1760737596 cites W1973213274 @default.
- W1760737596 cites W1978266275 @default.
- W1760737596 cites W1980265223 @default.
- W1760737596 cites W1988204115 @default.
- W1760737596 cites W1989775655 @default.
- W1760737596 cites W1990079644 @default.
- W1760737596 cites W1995852668 @default.
- W1760737596 cites W1999800461 @default.
- W1760737596 cites W2000916689 @default.
- W1760737596 cites W2001708377 @default.
- W1760737596 cites W2009155636 @default.
- W1760737596 cites W2010279666 @default.
- W1760737596 cites W2011869472 @default.
- W1760737596 cites W2015317486 @default.
- W1760737596 cites W2018372951 @default.
- W1760737596 cites W2020420593 @default.
- W1760737596 cites W2021025567 @default.
- W1760737596 cites W2022106990 @default.
- W1760737596 cites W2029615677 @default.
- W1760737596 cites W2032199944 @default.
- W1760737596 cites W2033700192 @default.
- W1760737596 cites W2033984917 @default.
- W1760737596 cites W2037398482 @default.
- W1760737596 cites W2038574106 @default.
- W1760737596 cites W2040378243 @default.
- W1760737596 cites W2041470800 @default.
- W1760737596 cites W2043643808 @default.
- W1760737596 cites W2044480762 @default.
- W1760737596 cites W2046156715 @default.
- W1760737596 cites W2051308399 @default.
- W1760737596 cites W2059724763 @default.
- W1760737596 cites W2064857569 @default.
- W1760737596 cites W2070178640 @default.
- W1760737596 cites W2071895413 @default.
- W1760737596 cites W2079127306 @default.
- W1760737596 cites W2087123550 @default.
- W1760737596 cites W2088048981 @default.
- W1760737596 cites W2091682505 @default.
- W1760737596 cites W2103540136 @default.
- W1760737596 cites W2110007780 @default.
- W1760737596 cites W2128117717 @default.
- W1760737596 cites W2133095517 @default.
- W1760737596 cites W2133989711 @default.
- W1760737596 cites W2140632605 @default.
- W1760737596 cites W2146545943 @default.
- W1760737596 cites W2166439728 @default.
- W1760737596 cites W2222343400 @default.
- W1760737596 cites W2234082005 @default.
- W1760737596 cites W2264340067 @default.
- W1760737596 cites W2266714865 @default.
- W1760737596 cites W2345674670 @default.
- W1760737596 cites W2399236422 @default.
- W1760737596 cites W2432871537 @default.
- W1760737596 cites W2469607834 @default.
- W1760737596 cites W2758871505 @default.
- W1760737596 cites W1797725013 @default.
- W1760737596 doi "https://doi.org/10.1096/fasebj.8.9.7516300" @default.
- W1760737596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7516300" @default.
- W1760737596 hasPublicationYear "1994" @default.
- W1760737596 type Work @default.
- W1760737596 sameAs 1760737596 @default.
- W1760737596 citedByCount "272" @default.
- W1760737596 countsByYear W17607375962012 @default.
- W1760737596 countsByYear W17607375962013 @default.
- W1760737596 countsByYear W17607375962014 @default.
- W1760737596 countsByYear W17607375962015 @default.
- W1760737596 countsByYear W17607375962016 @default.
- W1760737596 countsByYear W17607375962017 @default.
- W1760737596 countsByYear W17607375962018 @default.
- W1760737596 countsByYear W17607375962019 @default.
- W1760737596 countsByYear W17607375962020 @default.
- W1760737596 countsByYear W17607375962021 @default.
- W1760737596 countsByYear W17607375962022 @default.
- W1760737596 countsByYear W17607375962023 @default.
- W1760737596 crossrefType "journal-article" @default.
- W1760737596 hasAuthorship W1760737596A5014156549 @default.
- W1760737596 hasAuthorship W1760737596A5034601735 @default.
- W1760737596 hasBestOaLocation W17607375961 @default.
- W1760737596 hasConcept C107872376 @default.
- W1760737596 hasConcept C12554922 @default.
- W1760737596 hasConcept C150903083 @default.
- W1760737596 hasConcept C178790620 @default.
- W1760737596 hasConcept C181911157 @default.