Matches in SemOpenAlex for { <https://semopenalex.org/work/W1760841023> ?p ?o ?g. }
- W1760841023 endingPage "2124" @default.
- W1760841023 startingPage "2115" @default.
- W1760841023 abstract "Human adipose-derived stem cells (hADSCs) can differentiate into various cell types depending on chemical and topographical cues. One topographical cue recently noted to be successful in inducing differentiation is the nanoengineered polystyrene surface containing nanopore array-patterned substrate (NP substrate), which is designed to mimic the nanoscale topographical features of the extracellular matrix. In this study, efficacies of NP and flat substrates in inducing neural differentiation of hADSCs were examined by comparing their substrate-cell adhesion rates, filopodia growth, nuclei elongation, and expression of neural-specific markers. The polystyrene nano Petri dishes containing NP substrates were fabricated by a nano injection molding process using a nickel electroformed nano-mold insert (Diameter: 200 nm. Depth of pore: 500 nm. Center-to-center distance: 500 nm). Cytoskeleton and filopodia structures were observed by scanning electron microscopy and F-actin staining, while cell adhesion was tested by vinculin staining after 24 and 48 h of seeding. Expression of neural specific markers was examined by real-time quantitative polymerase chain reaction and immunocytochemistry. Results showed that NP substrates lead to greater substrate-cell adhesion, filopodia growth, nuclei elongation, and expression of neural specific markers compared to flat substrates. These results not only show the advantages of NP substrates, but they also suggest that further study into cell-substrate interactions may yield great benefits for biomaterial engineering." @default.
- W1760841023 created "2016-06-24" @default.
- W1760841023 creator A5006787063 @default.
- W1760841023 creator A5011113282 @default.
- W1760841023 creator A5035293838 @default.
- W1760841023 creator A5043888661 @default.
- W1760841023 creator A5052443616 @default.
- W1760841023 creator A5058106720 @default.
- W1760841023 creator A5063822726 @default.
- W1760841023 creator A5064706570 @default.
- W1760841023 creator A5067386748 @default.
- W1760841023 date "2015-07-01" @default.
- W1760841023 modified "2023-09-26" @default.
- W1760841023 title "Nanoengineered Polystyrene Surfaces with Nanopore Array Pattern Alters Cytoskeleton Organization and Enhances Induction of Neural Differentiation of Human Adipose-Derived Stem Cells" @default.
- W1760841023 cites W1534389116 @default.
- W1760841023 cites W1555234552 @default.
- W1760841023 cites W1964974921 @default.
- W1760841023 cites W1966420048 @default.
- W1760841023 cites W1968036386 @default.
- W1760841023 cites W1968421448 @default.
- W1760841023 cites W1973495017 @default.
- W1760841023 cites W1974452230 @default.
- W1760841023 cites W1975422671 @default.
- W1760841023 cites W1978661070 @default.
- W1760841023 cites W1987145582 @default.
- W1760841023 cites W1993799862 @default.
- W1760841023 cites W1995139987 @default.
- W1760841023 cites W1998454830 @default.
- W1760841023 cites W2010306109 @default.
- W1760841023 cites W2015947716 @default.
- W1760841023 cites W2018486224 @default.
- W1760841023 cites W2026008499 @default.
- W1760841023 cites W2029925436 @default.
- W1760841023 cites W2035534054 @default.
- W1760841023 cites W2038634187 @default.
- W1760841023 cites W2038722569 @default.
- W1760841023 cites W2038957336 @default.
- W1760841023 cites W2042715436 @default.
- W1760841023 cites W2049664704 @default.
- W1760841023 cites W2057163696 @default.
- W1760841023 cites W2057564766 @default.
- W1760841023 cites W2059717168 @default.
- W1760841023 cites W2067614509 @default.
- W1760841023 cites W2071263138 @default.
- W1760841023 cites W2072735892 @default.
- W1760841023 cites W2082067280 @default.
- W1760841023 cites W2087917743 @default.
- W1760841023 cites W2090598965 @default.
- W1760841023 cites W2091590811 @default.
- W1760841023 cites W2093987592 @default.
- W1760841023 cites W2096221523 @default.
- W1760841023 cites W2100200554 @default.
- W1760841023 cites W2108038175 @default.
- W1760841023 cites W2109162737 @default.
- W1760841023 cites W2112502390 @default.
- W1760841023 cites W2115062578 @default.
- W1760841023 cites W2131980222 @default.
- W1760841023 cites W2135025709 @default.
- W1760841023 cites W2137381294 @default.
- W1760841023 cites W2137452172 @default.
- W1760841023 cites W2153368716 @default.
- W1760841023 cites W2170271633 @default.
- W1760841023 cites W2184002237 @default.
- W1760841023 doi "https://doi.org/10.1089/ten.tea.2014.0346" @default.
- W1760841023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25919423" @default.
- W1760841023 hasPublicationYear "2015" @default.
- W1760841023 type Work @default.
- W1760841023 sameAs 1760841023 @default.
- W1760841023 citedByCount "19" @default.
- W1760841023 countsByYear W17608410232016 @default.
- W1760841023 countsByYear W17608410232017 @default.
- W1760841023 countsByYear W17608410232018 @default.
- W1760841023 countsByYear W17608410232019 @default.
- W1760841023 countsByYear W17608410232020 @default.
- W1760841023 countsByYear W17608410232021 @default.
- W1760841023 countsByYear W17608410232022 @default.
- W1760841023 countsByYear W17608410232023 @default.
- W1760841023 crossrefType "journal-article" @default.
- W1760841023 hasAuthorship W1760841023A5006787063 @default.
- W1760841023 hasAuthorship W1760841023A5011113282 @default.
- W1760841023 hasAuthorship W1760841023A5035293838 @default.
- W1760841023 hasAuthorship W1760841023A5043888661 @default.
- W1760841023 hasAuthorship W1760841023A5052443616 @default.
- W1760841023 hasAuthorship W1760841023A5058106720 @default.
- W1760841023 hasAuthorship W1760841023A5063822726 @default.
- W1760841023 hasAuthorship W1760841023A5064706570 @default.
- W1760841023 hasAuthorship W1760841023A5067386748 @default.
- W1760841023 hasConcept C12554922 @default.
- W1760841023 hasConcept C136834591 @default.
- W1760841023 hasConcept C1491633281 @default.
- W1760841023 hasConcept C159985019 @default.
- W1760841023 hasConcept C171250308 @default.
- W1760841023 hasConcept C185592680 @default.
- W1760841023 hasConcept C18903297 @default.
- W1760841023 hasConcept C189165786 @default.
- W1760841023 hasConcept C192562407 @default.
- W1760841023 hasConcept C2777289219 @default.
- W1760841023 hasConcept C2777803738 @default.