FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1760936225> ?p ?o ?g. }

• W1760936225 endingPage "1082" @default.
• W1760936225 startingPage "1069" @default.
• W1760936225 abstract "Abstract Caenorhabditis elegans locomotion is a complex behavior generated by a defined set of motor neurons and interneurons. Genetic analysis shows that UNC-43, the C. elegans Ca2+/calmodulin protein kinase II (CaMKII), controls locomotion rate. Elevated UNC-43 activity, from a gain-of-function mutation, causes severely lethargic locomotion, presumably by inappropriate phosphorylation of targets. In a genetic screen for suppressors of this phenotype, we identified multiple alleles of four genes in a Go/Gq G-protein signaling network, which has been shown to regulate synaptic activity via diacylglycerol. Mutations in goa-1, dgk-1, eat-16, or eat-11 strongly or completely suppressed unc-43(gf) lethargy, but affected other mutants with reduced locomotion only weakly. We conclude that CaMKII and Go/Gq pathways act in concert to regulate synaptic activity, perhaps through a direct interaction between CaMKII and Go." @default.
• W1760936225 created "2016-06-24" @default.
• W1760936225 creator A5010953407 @default.
• W1760936225 creator A5054663579 @default.
• W1760936225 date "2000-11-01" @default.
• W1760936225 modified "2023-10-01" @default.
• W1760936225 title "Calcium/Calmodulin-Dependent Protein Kinase II Regulates <i>Caenorhabditis elegans</i> Locomotion in Concert With a Go/Gq Signaling Network" @default.
• W1760936225 cites W1504478980 @default.
• W1760936225 cites W1570939625 @default.
• W1760936225 cites W1630027754 @default.
• W1760936225 cites W1659153222 @default.
• W1760936225 cites W1904905451 @default.
• W1760936225 cites W1944127002 @default.
• W1760936225 cites W1948927501 @default.
• W1760936225 cites W1964807138 @default.
• W1760936225 cites W1964817556 @default.
• W1760936225 cites W1971126847 @default.
• W1760936225 cites W1972760976 @default.
• W1760936225 cites W1977925481 @default.
• W1760936225 cites W1983218230 @default.
• W1760936225 cites W1989952069 @default.
• W1760936225 cites W1990656070 @default.
• W1760936225 cites W1991091954 @default.
• W1760936225 cites W1993678582 @default.
• W1760936225 cites W1996626314 @default.
• W1760936225 cites W2003078610 @default.
• W1760936225 cites W2008520902 @default.
• W1760936225 cites W2009821005 @default.
• W1760936225 cites W2009945174 @default.
• W1760936225 cites W2010920096 @default.
• W1760936225 cites W2011909683 @default.
• W1760936225 cites W2019319677 @default.
• W1760936225 cites W2022224180 @default.
• W1760936225 cites W2026068903 @default.
• W1760936225 cites W2027704731 @default.
• W1760936225 cites W2028679115 @default.
• W1760936225 cites W2029402031 @default.
• W1760936225 cites W2035880579 @default.
• W1760936225 cites W2037071509 @default.
• W1760936225 cites W2042338200 @default.
• W1760936225 cites W2045194954 @default.
• W1760936225 cites W2051584218 @default.
• W1760936225 cites W2052322593 @default.
• W1760936225 cites W2052773849 @default.
• W1760936225 cites W2054975255 @default.
• W1760936225 cites W2057347947 @default.
• W1760936225 cites W2058615553 @default.
• W1760936225 cites W2073223681 @default.
• W1760936225 cites W2074821443 @default.
• W1760936225 cites W2080152563 @default.
• W1760936225 cites W2087444241 @default.
• W1760936225 cites W2088777486 @default.
• W1760936225 cites W2092111364 @default.
• W1760936225 cites W2095139816 @default.
• W1760936225 cites W2110458673 @default.
• W1760936225 cites W2133321625 @default.
• W1760936225 cites W2135011583 @default.
• W1760936225 cites W2151285918 @default.
• W1760936225 cites W2157166663 @default.
• W1760936225 cites W2158016476 @default.
• W1760936225 cites W2158350175 @default.
• W1760936225 cites W2160938187 @default.
• W1760936225 cites W2164804804 @default.
• W1760936225 cites W2180781622 @default.
• W1760936225 cites W2187773005 @default.
• W1760936225 cites W2344424992 @default.
• W1760936225 doi "https://doi.org/10.1093/genetics/156.3.1069" @default.
• W1760936225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461315" @default.
• W1760936225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11063685" @default.
• W1760936225 hasPublicationYear "2000" @default.
• W1760936225 type Work @default.
• W1760936225 sameAs 1760936225 @default.
• W1760936225 citedByCount "68" @default.
• W1760936225 countsByYear W17609362252012 @default.
• W1760936225 countsByYear W17609362252013 @default.
• W1760936225 countsByYear W17609362252014 @default.
• W1760936225 countsByYear W17609362252015 @default.
• W1760936225 countsByYear W17609362252016 @default.
• W1760936225 countsByYear W17609362252019 @default.
• W1760936225 countsByYear W17609362252021 @default.
• W1760936225 countsByYear W17609362252022 @default.
• W1760936225 countsByYear W17609362252023 @default.
• W1760936225 crossrefType "journal-article" @default.
• W1760936225 hasAuthorship W1760936225A5010953407 @default.
• W1760936225 hasAuthorship W1760936225A5054663579 @default.
• W1760936225 hasBestOaLocation W17609362252 @default.
• W1760936225 hasConcept C104317684 @default.
• W1760936225 hasConcept C11960822 @default.
• W1760936225 hasConcept C127716648 @default.
• W1760936225 hasConcept C143065580 @default.
• W1760936225 hasConcept C181199279 @default.
• W1760936225 hasConcept C195794163 @default.
• W1760936225 hasConcept C207177822 @default.
• W1760936225 hasConcept C2778944004 @default.
• W1760936225 hasConcept C29688787 @default.
• W1760936225 hasConcept C36020004 @default.
• W1760936225 hasConcept C501734568 @default.
• W1760936225 hasConcept C54355233 @default.

• next