FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W176147796> ?p ?o ?g. }

• W176147796 endingPage "232" @default.
• W176147796 startingPage "217" @default.
• W176147796 abstract "Covalent attachment of lipophilic moieties to proteins influences interaction with membranes and membrane microdomains, as well as signal transduction. The most common forms of fatty acylation include modification of the N-terminal glycine of proteins by N-myristoylation and/or attachment of palmitate to internal cysteine residues. Protein prenylation involves attachment of farnesyl or geranylgeranyl moieties via thio-ether linkage to cysteine residues at or near the C-terminus. Attachment of each of these lipophilic groups is catalyzed by a distinct enzyme or set of enzymes: N-myristoyl transferase for N-myristoylation, palmitoyl acyl transferases for palmitoylation, and farnesyl or geranylgeranyl transferases for prenylation. The distinct nature of the lipid modification determines the strength of membrane interaction of the modified protein as well as the specificity of membrane targeting. Clusters of basic residues can also synergize with the lipophilic group to promote membrane binding and targeting. The final destination of the modified protein is influenced by multiple factors, including the localization of the modifying enzymes, protein/protein interactions, and the lipid composition of the acceptor membrane. In particular, much interest has been focused on the ability of fatty acylated proteins to preferentially partition into membrane rafts, subdomains of the plasma membrane that are enriched in cholesterol and glycosphingolipids. Lipid raft localization is necessary for efficient signal transduction in a wide variety of systems, including signaling by T and B cell receptors, Ras, and growth factor receptors. However, certain membrane subdomains, such as caveolae, can serve as reservoirs for inactive signaling proteins. Heterogeneity in the types of membrane subdomains, as well as in the types of lipophilic groups that are attached to proteins, provide an additional level of complexity in the regulation of signaling by membrane bound proteins." @default.
• W176147796 created "2016-06-24" @default.
• W176147796 creator A5027044141 @default.
• W176147796 date "2004-01-01" @default.
• W176147796 modified "2023-10-18" @default.
• W176147796 title "Membrane Targeting of Lipid Modified Signal Transduction Proteins" @default.
• W176147796 cites W1494227533 @default.
• W176147796 cites W1512968077 @default.
• W176147796 cites W1513667798 @default.
• W176147796 cites W1564861448 @default.
• W176147796 cites W1579191879 @default.
• W176147796 cites W1580353693 @default.
• W176147796 cites W1607303892 @default.
• W176147796 cites W1607802573 @default.
• W176147796 cites W1633029073 @default.
• W176147796 cites W1799140375 @default.
• W176147796 cites W1804930604 @default.
• W176147796 cites W1852817901 @default.
• W176147796 cites W1963729107 @default.
• W176147796 cites W1966434597 @default.
• W176147796 cites W1966998035 @default.
• W176147796 cites W1968453135 @default.
• W176147796 cites W1968487175 @default.
• W176147796 cites W1975449649 @default.
• W176147796 cites W1976551834 @default.
• W176147796 cites W1982130978 @default.
• W176147796 cites W1984247884 @default.
• W176147796 cites W1986930808 @default.
• W176147796 cites W1988530230 @default.
• W176147796 cites W1991402029 @default.
• W176147796 cites W1998865212 @default.
• W176147796 cites W1999175477 @default.
• W176147796 cites W1999678180 @default.
• W176147796 cites W2003625629 @default.
• W176147796 cites W2003894360 @default.
• W176147796 cites W2006008134 @default.
• W176147796 cites W2006060580 @default.
• W176147796 cites W2007312416 @default.
• W176147796 cites W2008264122 @default.
• W176147796 cites W2013789757 @default.
• W176147796 cites W2014451351 @default.
• W176147796 cites W2016364188 @default.
• W176147796 cites W2016851491 @default.
• W176147796 cites W2018458016 @default.
• W176147796 cites W2025646685 @default.
• W176147796 cites W2026273737 @default.
• W176147796 cites W2030943228 @default.
• W176147796 cites W2032062053 @default.
• W176147796 cites W2038126024 @default.
• W176147796 cites W2042269004 @default.
• W176147796 cites W2051002350 @default.
• W176147796 cites W2055864348 @default.
• W176147796 cites W2060343311 @default.
• W176147796 cites W2065886456 @default.
• W176147796 cites W2066887588 @default.
• W176147796 cites W2068504553 @default.
• W176147796 cites W2070660207 @default.
• W176147796 cites W2076606695 @default.
• W176147796 cites W2080494149 @default.
• W176147796 cites W2084250362 @default.
• W176147796 cites W2088436702 @default.
• W176147796 cites W2092437783 @default.
• W176147796 cites W2093182890 @default.
• W176147796 cites W2097353604 @default.
• W176147796 cites W2098301486 @default.
• W176147796 cites W2099555659 @default.
• W176147796 cites W2103201163 @default.
• W176147796 cites W2106230884 @default.
• W176147796 cites W2114844324 @default.
• W176147796 cites W2115037258 @default.
• W176147796 cites W2115051410 @default.
• W176147796 cites W2121503187 @default.
• W176147796 cites W2127444703 @default.
• W176147796 cites W2128963767 @default.
• W176147796 cites W2131281845 @default.
• W176147796 cites W2131423590 @default.
• W176147796 cites W2132543766 @default.
• W176147796 cites W2134539481 @default.
• W176147796 cites W2134701313 @default.
• W176147796 cites W2135955581 @default.
• W176147796 cites W2142475134 @default.
• W176147796 cites W2149308201 @default.
• W176147796 cites W2152189564 @default.
• W176147796 cites W2152401699 @default.
• W176147796 cites W2162030013 @default.
• W176147796 cites W2162884305 @default.
• W176147796 cites W2163617508 @default.
• W176147796 cites W2165803049 @default.
• W176147796 cites W2167042104 @default.
• W176147796 cites W2411799433 @default.
• W176147796 cites W4252818752 @default.
• W176147796 cites W95054676 @default.
• W176147796 doi "https://doi.org/10.1007/978-1-4757-5806-1_6" @default.
• W176147796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15376622" @default.
• W176147796 hasPublicationYear "2004" @default.
• W176147796 type Work @default.
• W176147796 sameAs 176147796 @default.
• W176147796 citedByCount "193" @default.

• next