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• W176205669 endingPage "251" @default.
• W176205669 startingPage "235" @default.
• W176205669 abstract "Heat shock proteins have been detected in many mammalian tissues, including the nervous system. In recent years, the family of small molecular weight heat shock proteins, Hsp27, Hsp32 (heme oxygenase), and αB-crystallin, have been shown to be similarly expressed and regulated in response to a variety of challenges. While Hsp27 has been detected in several organs in mammals (Klemenz et al. 1993; Tanguay et al. 1993), its expression and distribution in the central nervous system are particularly striking in both development and in the adult, normally and after pathophysiological challenge. Therefore, in this chapter, we will focus on the expression of Hsp27 in the nervous system. In our work we have focused on the constitutive and pathophysiological expression of Hsp27, particularly in comparison to Hsp70. In the central and peripheral nervous systems, Hsp27 is expressed constitutively in well-defined subsets of neurons but only occasionally in neuroglia. In contrast, expression of Hsp27 in neurons and neuroglia is markedly increased in response to physiological challenges and in various models of nervous system injury, leading to the idea of specific cell-type, stress-dependent expression of Hsp27. While little is known about the role of Hsp27 in neurodegenerative diseases, their detection in these diseases leads one to consider whether such expression is beneficial and slows the degenerative process or is detrimental and indicative of the severity of the disease process. The present chapter will emphasize results on the expression of Hsp27 in the nervous system after various challenges." @default.
• W176205669 created "2016-06-24" @default.
• W176205669 creator A5038190324 @default.
• W176205669 creator A5038595912 @default.
• W176205669 creator A5047163502 @default.
• W176205669 creator A5075196738 @default.
• W176205669 date "2002-01-01" @default.
• W176205669 modified "2023-09-24" @default.
• W176205669 title "Hsp27 in the Nervous System: Expression in Pathophysiology and in the Aging Brain" @default.
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• W176205669 doi "https://doi.org/10.1007/978-3-642-56348-5_13" @default.

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