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- W1762331628 abstract "Abstract Tumor growth is angiogenesis dependent. Angiogenic switch (the acquisition of an angiogenic phenotype) is essential for cervical carcinogenesis. Thrombospondin-1 (TSP-1) is an endogenous angiogenic inhibitor with multiple functional domains and interacting receptors. The disruption of TSP-1 fence (the expression in basal epithelia) occurred concordantly during the transition from low-grade squamous intraepithelial lesion into high-grade squamous intraepithelial lesion. This concordance suggests that TSP-1 plays a role in the regulation of angiogenic switch during cervical carcinogenesis. Tumor vasculature as a therapeutic target offers a paradigm shift for anticancer therapy. Endothelial cells do not appear to acquire resistance during antiangiogenic therapy. Low-and-frequent dose “metronic” chemotherapy is found to be antiangiogenic, which is more effective in targeting tumor endothelia than traditional large, single bolus doses. Meanwhile, the invasion process of cancers is associated with stroma reaction, which is characterized by fibroblasts' activation. In addition to the well-known angiogenesis inhibitor, TSP-1 also has a novel role of blocking activated fibroblasts (myofibroblasts) from invading cancer. Activated fibroblasts during stroma reaction could be used as an efficient drug delivery system to prevent or slow the local growth of cancer cells. Elucidation of the mechanism by which fibroblasts are recruited into cancer stroma could lead to new insights into not only the mechanisms of cancer progression but also strategies for cancer treatment. A better understanding of stromal contributions to cancer progression will likely result in the identification of new therapeutics targeting the stroma." @default.
- W1762331628 created "2016-06-24" @default.
- W1762331628 creator A5016968509 @default.
- W1762331628 creator A5017286773 @default.
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- W1762331628 date "2016-05-01" @default.
- W1762331628 modified "2023-10-03" @default.
- W1762331628 title "The anticancer potential of thrombospondin-1 by inhibiting angiogenesis and stroma reaction during cervical carcinogenesis" @default.
- W1762331628 cites W132059920 @default.
- W1762331628 cites W1482076735 @default.
- W1762331628 cites W1485875137 @default.
- W1762331628 cites W1495198008 @default.
- W1762331628 cites W1497663490 @default.
- W1762331628 cites W1520425169 @default.
- W1762331628 cites W156576096 @default.
- W1762331628 cites W1573363574 @default.
- W1762331628 cites W1574172480 @default.
- W1762331628 cites W1595263809 @default.
- W1762331628 cites W1605580017 @default.
- W1762331628 cites W1650984530 @default.
- W1762331628 cites W1656339735 @default.
- W1762331628 cites W1658860190 @default.
- W1762331628 cites W1679229092 @default.
- W1762331628 cites W1933742170 @default.
- W1762331628 cites W1943173994 @default.
- W1762331628 cites W1964790409 @default.
- W1762331628 cites W1965172925 @default.
- W1762331628 cites W1965681130 @default.
- W1762331628 cites W1965909442 @default.
- W1762331628 cites W1972870829 @default.
- W1762331628 cites W1974210097 @default.
- W1762331628 cites W1978139448 @default.
- W1762331628 cites W1979307478 @default.
- W1762331628 cites W1983505913 @default.
- W1762331628 cites W1984584032 @default.
- W1762331628 cites W1984888076 @default.
- W1762331628 cites W1985727076 @default.
- W1762331628 cites W1985804036 @default.
- W1762331628 cites W1988850323 @default.
- W1762331628 cites W1993246798 @default.
- W1762331628 cites W1994360534 @default.
- W1762331628 cites W2000307014 @default.
- W1762331628 cites W2002220495 @default.
- W1762331628 cites W2007672298 @default.
- W1762331628 cites W2008714016 @default.
- W1762331628 cites W2010293565 @default.
- W1762331628 cites W2019883573 @default.
- W1762331628 cites W2022662750 @default.
- W1762331628 cites W2023116221 @default.
- W1762331628 cites W2023921074 @default.
- W1762331628 cites W2024626734 @default.
- W1762331628 cites W2027894802 @default.
- W1762331628 cites W2028714887 @default.
- W1762331628 cites W2029883816 @default.
- W1762331628 cites W2031300004 @default.
- W1762331628 cites W2031775841 @default.
- W1762331628 cites W2032511198 @default.
- W1762331628 cites W2039898357 @default.
- W1762331628 cites W2053056834 @default.
- W1762331628 cites W2059294866 @default.
- W1762331628 cites W2062089640 @default.
- W1762331628 cites W2073495853 @default.
- W1762331628 cites W2073608758 @default.
- W1762331628 cites W2076040050 @default.
- W1762331628 cites W2078247661 @default.
- W1762331628 cites W2078502914 @default.
- W1762331628 cites W2084513598 @default.
- W1762331628 cites W2085939705 @default.
- W1762331628 cites W2087945154 @default.
- W1762331628 cites W2088978805 @default.
- W1762331628 cites W2090094486 @default.
- W1762331628 cites W2092898578 @default.
- W1762331628 cites W2100756525 @default.
- W1762331628 cites W2102392974 @default.
- W1762331628 cites W2112910223 @default.
- W1762331628 cites W2118590366 @default.
- W1762331628 cites W2126099136 @default.
- W1762331628 cites W2127449951 @default.
- W1762331628 cites W2131798870 @default.
- W1762331628 cites W2134953299 @default.
- W1762331628 cites W2135114065 @default.
- W1762331628 cites W2142149740 @default.
- W1762331628 cites W2160687667 @default.
- W1762331628 cites W2161714684 @default.
- W1762331628 cites W2166315000 @default.
- W1762331628 cites W2169965478 @default.
- W1762331628 cites W2172170762 @default.
- W1762331628 cites W2320996 @default.
- W1762331628 cites W232361230 @default.
- W1762331628 cites W2419406559 @default.
- W1762331628 cites W2471274090 @default.
- W1762331628 cites W2069305509 @default.
- W1762331628 doi "https://doi.org/10.1016/j.gmit.2015.09.001" @default.
- W1762331628 hasPublicationYear "2016" @default.
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