Matches in SemOpenAlex for { <https://semopenalex.org/work/W1762360147> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1762360147 endingPage "241" @default.
- W1762360147 startingPage "236" @default.
- W1762360147 abstract "Summary We characterized a symptomatic CRMred factor X (FX) deficiency produced by the Glu19Ala mutation in the γ-carboxyglutamic-rich domain. FX activity levels in plasma were markedly reduced in prothrombin time assays (< 1-5%), whereas in activated partial thromboplastin assays (16%) and in RVV assays (17%) the reduction in activity mirrored that in antigen levels (17%). Activation of recombinant 19Ala-FX by factor IXa/factor VIIIa or RVV, and the activity in thrombin generation assays, were comparable to those of wild-type FX. Differently, complete activation of recombinant 19AlaFX required a factor VIIa/TF concentration 30-fold higher than that of wild-type FX. The recombinant FVIIa significantly reduced PT values in 19Ala-FX reconstituted plasma, thus suggesting an alternative approach for treatment of FX deficiencies characterized by defective FX activation. The study of this FX deficiency provides an “in vivo” and “in vitro” model for the investigation of Gla domain interactions." @default.
- W1762360147 created "2016-06-24" @default.
- W1762360147 creator A5029202139 @default.
- W1762360147 creator A5052974645 @default.
- W1762360147 creator A5057403590 @default.
- W1762360147 creator A5060145568 @default.
- W1762360147 creator A5065749799 @default.
- W1762360147 creator A5077653255 @default.
- W1762360147 date "2002-01-01" @default.
- W1762360147 modified "2023-10-12" @default.
- W1762360147 title "Reduced Activation of the Gla19Ala FX Variant via the Extrinsic Coagulation Pathway Results in Symptomatic CRMred FX Deficiency" @default.
- W1762360147 doi "https://doi.org/10.1055/s-0037-1613193" @default.
- W1762360147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12195695" @default.
- W1762360147 hasPublicationYear "2002" @default.
- W1762360147 type Work @default.
- W1762360147 sameAs 1762360147 @default.
- W1762360147 citedByCount "21" @default.
- W1762360147 countsByYear W17623601472012 @default.
- W1762360147 countsByYear W17623601472014 @default.
- W1762360147 countsByYear W17623601472015 @default.
- W1762360147 countsByYear W17623601472019 @default.
- W1762360147 countsByYear W17623601472020 @default.
- W1762360147 crossrefType "journal-article" @default.
- W1762360147 hasAuthorship W1762360147A5029202139 @default.
- W1762360147 hasAuthorship W1762360147A5052974645 @default.
- W1762360147 hasAuthorship W1762360147A5057403590 @default.
- W1762360147 hasAuthorship W1762360147A5060145568 @default.
- W1762360147 hasAuthorship W1762360147A5065749799 @default.
- W1762360147 hasAuthorship W1762360147A5077653255 @default.
- W1762360147 hasConcept C104317684 @default.
- W1762360147 hasConcept C126322002 @default.
- W1762360147 hasConcept C144594695 @default.
- W1762360147 hasConcept C150903083 @default.
- W1762360147 hasConcept C153911025 @default.
- W1762360147 hasConcept C185592680 @default.
- W1762360147 hasConcept C186738567 @default.
- W1762360147 hasConcept C207001950 @default.
- W1762360147 hasConcept C2777292125 @default.
- W1762360147 hasConcept C2777444498 @default.
- W1762360147 hasConcept C2778261982 @default.
- W1762360147 hasConcept C2778382381 @default.
- W1762360147 hasConcept C2778961111 @default.
- W1762360147 hasConcept C2780434524 @default.
- W1762360147 hasConcept C2910886357 @default.
- W1762360147 hasConcept C3018972837 @default.
- W1762360147 hasConcept C40767141 @default.
- W1762360147 hasConcept C55493867 @default.
- W1762360147 hasConcept C71924100 @default.
- W1762360147 hasConcept C86803240 @default.
- W1762360147 hasConcept C89560881 @default.
- W1762360147 hasConceptScore W1762360147C104317684 @default.
- W1762360147 hasConceptScore W1762360147C126322002 @default.
- W1762360147 hasConceptScore W1762360147C144594695 @default.
- W1762360147 hasConceptScore W1762360147C150903083 @default.
- W1762360147 hasConceptScore W1762360147C153911025 @default.
- W1762360147 hasConceptScore W1762360147C185592680 @default.
- W1762360147 hasConceptScore W1762360147C186738567 @default.
- W1762360147 hasConceptScore W1762360147C207001950 @default.
- W1762360147 hasConceptScore W1762360147C2777292125 @default.
- W1762360147 hasConceptScore W1762360147C2777444498 @default.
- W1762360147 hasConceptScore W1762360147C2778261982 @default.
- W1762360147 hasConceptScore W1762360147C2778382381 @default.
- W1762360147 hasConceptScore W1762360147C2778961111 @default.
- W1762360147 hasConceptScore W1762360147C2780434524 @default.
- W1762360147 hasConceptScore W1762360147C2910886357 @default.
- W1762360147 hasConceptScore W1762360147C3018972837 @default.
- W1762360147 hasConceptScore W1762360147C40767141 @default.
- W1762360147 hasConceptScore W1762360147C55493867 @default.
- W1762360147 hasConceptScore W1762360147C71924100 @default.
- W1762360147 hasConceptScore W1762360147C86803240 @default.
- W1762360147 hasConceptScore W1762360147C89560881 @default.
- W1762360147 hasIssue "08" @default.
- W1762360147 hasLocation W17623601471 @default.
- W1762360147 hasLocation W17623601472 @default.
- W1762360147 hasOpenAccess W1762360147 @default.
- W1762360147 hasPrimaryLocation W17623601471 @default.
- W1762360147 hasRelatedWork W139274608 @default.
- W1762360147 hasRelatedWork W1519862745 @default.
- W1762360147 hasRelatedWork W2043671350 @default.
- W1762360147 hasRelatedWork W2063199350 @default.
- W1762360147 hasRelatedWork W2063643460 @default.
- W1762360147 hasRelatedWork W2070386451 @default.
- W1762360147 hasRelatedWork W2395704785 @default.
- W1762360147 hasRelatedWork W3096096267 @default.
- W1762360147 hasRelatedWork W4231065736 @default.
- W1762360147 hasRelatedWork W68354926 @default.
- W1762360147 hasVolume "88" @default.
- W1762360147 isParatext "false" @default.
- W1762360147 isRetracted "false" @default.
- W1762360147 magId "1762360147" @default.
- W1762360147 workType "article" @default.