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- W176240631 endingPage "35" @default.
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- W176240631 abstract "The recognition of cancer as a genetic disease has brought with it the observation that tumor development is the outcome of multiple independent mutational events occurring during somatic tissue growth (Peto et al. 1975; Fearon and Vogelstein 1990). These mutations in combination lead to abnormalities in growth control and genome instability in cancer cells. Advances in model organism studies have shown that these two attributes are frequently linked; that abnormalities in the control of cell cycle progression are often associated with increased errors in replicating and transmitting the parental genome to daughter cells. Because fundamental aspects of cell cycle control and chromosome distribution are clearly conserved in eukaryotic organisms, studies in model experimental systems are highly relevant to elucidation of the roles of these processes in tumor development in humans (Hartwell and Kastan 1994). This review will focus on recent advances in cell cycle control and genetic instability in the budding yeast Saccharomyces cerevisiae, with emphasis on experimental topics in which loss of cell cycle progression control decreases the fidelity of chromosome transmission to daughter cells. Viable single gene mutations that perturb both cell cycle control and genome stability in model organisms represent promising candidate tumor suppressor homologues. At this time, the connections between these functions in yeast and mammalian carcinogenesis are largely speculative, although the parallels are strong and warrant consideration." @default.
- W176240631 created "2016-06-24" @default.
- W176240631 creator A5079003049 @default.
- W176240631 date "1997-01-01" @default.
- W176240631 modified "2023-09-24" @default.
- W176240631 title "Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis" @default.
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- W176240631 doi "https://doi.org/10.1007/978-3-642-60505-5_3" @default.
- W176240631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8979438" @default.
- W176240631 hasPublicationYear "1997" @default.
- W176240631 type Work @default.